Zhou, Jie’s team published research in Journal of Chromatography A in 1467 | CAS: 69097-99-0

Journal of Chromatography A published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C18H22O4, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Zhou, Jie published the artcileCationic cyclodextrin clicked chiral stationary phase for versatile enantioseparations in high-performance liquid chromatography, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, the publication is Journal of Chromatography A (2016), 169-177, database is CAplus and MEDLINE.

A novel cationic cyclodextrin (CD) chiral stationary phase (CSPs) was developed by clicking 6A-azido-6C-[(3-methoxylpropyl)-1- ammonium]-heptakis[2,3-di-O-(3-chloro-4-methylphenylcarbamate)-6B,6D,6E,6F,6G-pentakis-O-per(3-chloro-4-methylphenylcarbamate)]-β-CD chloride onto alkynyl silica support. The enantioselectivies of the as-obtained novel CSP were evaluated using 21 model racemates including flavonoids, aromatic alcs., acidic drugs, β-blocker and amino acids. Good enantioseparations were achieved in polar-organic phase HPLC, with the highest resolution of 8.07 observed for 7-methoxyflavanone. The enantioseparations in normal-phase HPLC were fine-tuned with the polarity of the mobile phase with different alcs. as organic modifiers. Improved chiral resolutions of analytes but longer retention were observed in mobile phases with decreased polarity. On comparison with previously reported clicked CD CSP, the cationic CD clicked CSP exhibited better enenatiosepns. for selected racemates even in normal-phase HPLC. 3-Methoxypropylammonium and phenylcarbamoylated moieties of the cationic CSP may provide intermol. interactions such as hydrogen bonding, π-π conjugation and dipole-dipole besides inclusion complexation to drive the enantioseparation

Journal of Chromatography A published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C18H22O4, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics