Xu, Jing published the artcilePolyphenols from acorn leaves (Quercus liaotungensis) protect pancreatic beta cells and their inhibitory activity against a-glucosidase and protein tyrosine phosphatase 1B, Application In Synthesis of 69097-99-0, the publication is Molecules (2018), 23(9), 2167/1-2167/12, database is CAplus and MEDLINE.
Acorn leaves, which possess potential pharmacol. effects, are traditionally consumed as food in China. Phytochem. investigations of acorn leaves yielded one new and 25 known polyphenols, and their structures were identified by extensive spectroscopic anal. Three antidiabetes assays were conducted. Compound 2 considerably increased the survival of pancreatic beta cells by reducing the production of reactive oxygen species and enhancing the activities of superoxide dismutase, catalase, and glutathione in MIN6 cells damaged by H2O2. The preliminary mechanism by which compound 2 protects pancreatic beta cells was through the nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 HO-1 pathway. Most of the tested isolates showed strong inhibitory activity against a-glucosidase and protein tyrosine phosphatase 1B. The IC50 values of most compounds were much lower than those of the pos. control. The results suggest that polyphenols from acorn leaves are potential functional food ingredients that can be used as antidiabetic agents.
Molecules published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C8H5F3N4, Application In Synthesis of 69097-99-0.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics