Kahyo, Tomoaki’s team published research in Journal of Pharmacological Sciences (Tokyo, Japan) in 108 | CAS: 69097-99-0

Journal of Pharmacological Sciences (Tokyo, Japan) published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Synthetic Route of 69097-99-0.

Kahyo, Tomoaki published the artcileA novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells, Synthetic Route of 69097-99-0, the publication is Journal of Pharmacological Sciences (Tokyo, Japan) (2008), 108(3), 364-371, database is CAplus and MEDLINE.

SIRT1 is one of seven mammalian orthologs of yeast silent information regulator 2 (Sir2), and it functions as a NAD (NAD)-dependent deacetylase. Recently, resveratrol and its analogs, which are polyphenols, have been reported to activate the deacetylase activity of SIRT1 in an in vitro assay and to expand the life-span of several species through Sir2 and the orthologs. To find activators or inhibitors to SIRT1, we examined thirty-six polyphenols, including stilbenes, chalcones, flavanones, and flavonols, with the SIRT1 deacetylase activity assay using the acetylated peptide of p53 as a substrate. The results showed that 3,2′,3′,4′-tetrahydroxychalcone, a newly synthesized compound, inhibited the SIRT1-mediated deacetylation of a p53 acetylated peptide and recombinant protein in vitro. In addition, this agent induced the hyperacetylation of endogenous p53, increased the endogenous p21CIP1/WAF1 in intact cells, and suppressed the cell growth. These results indicated that 3,2′,3′,4′-tetrahydroxychalcone had a stronger inhibitory effect on the SIRT1-pathway than sirtinol, a known SIRT1-inhibitor. Our results mean that 3,2′,3′,4′-tetrahydroxychalcone is a novel inhibitor of SIRT1 and produces physiol. effects on organisms probably through inhibiting the deacetylation by SIRT1.

Journal of Pharmacological Sciences (Tokyo, Japan) published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Synthetic Route of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Baggiolini, Enrico G.’s team published research in Journal of Organic Chemistry in 51 | CAS: 27943-46-0

Journal of Organic Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Category: tetrahydropyran.

Baggiolini, Enrico G. published the artcileStereocontrolled total synthesis of 1α,25-dihydroxycholecalciferol and 1α,25-dihydroxyergocalciferol, Category: tetrahydropyran, the publication is Journal of Organic Chemistry (1986), 51(16), 3098-108, database is CAplus.

1α,25-Dihydroxycholecalciferol and 1α,25-dihydroxyergocalciferol, the hormonally active forms of vitamin D3 and vitamin D2, were prepd by Horner-Wittig reaction of the phosphine oxide I [R = CH2P(O)Ph2] (II) with ketones III and IV, resp. The synthon III was obtained via stereospecific opening of epoxide V with NaOAc in AcOH followed by oxidative degradation of the isopropenyl side chain and dehydration of the intermediate VI. Photoisomerization of the resulting (E)-I (R = CO2Et) gave I (R = CO2Et), which was converted to II. III was obtained from the known intermediate VII. The introduction of the 25-hydroxy side chain was achieved by reaction of the lithium derivative of HCCCMe2OR1 (R1 = tetrahydropyranyl) with the tosylate of VII; subsequent hydrogenation, deblocking, and oxidation reactions gaave III. IV was prepared by a stereocontrolled route that involves as the key step the [3 + 2] dipolar cycloaddition of nitrone VII with Me2C:CHCO2Me to give a 1:1 mixture of isoxazolidines IX. Stereochem. control was achieved by taking advantage of the thermal reversibility of the cycloaddition, which allows the reequilibration of undersired IX. (23S, 24S)-IX was readily transformed to amine X by reduction, followed by elimination of the nitrogen function, and finally oxidation to IV.

Journal of Organic Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Category: tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Nanayakkara, N. P. Dhammika’s team published research in Journal of Medicinal Chemistry in 31 | CAS: 69097-99-0

Journal of Medicinal Chemistry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Product Details of C16H14O6.

Nanayakkara, N. P. Dhammika published the artcilePotential sweetening agents of plant origin. 13. An intensely sweet dihydroflavonol derivative based on a natural product lead compound, Product Details of C16H14O6, the publication is Journal of Medicinal Chemistry (1988), 31(6), 1250-3, database is CAplus and MEDLINE.

Dihydroquercetin 3-acetate [(2R,3R)-I; R = Ac, R1 = H] (II) was isolated as a sweet constituent of the young shoots of Tessaria dodoneifolia (Hook. & Arn.) Cabrera (Compositae). II and I (R = Ac, R1 = Me), a novel synthetic analog of II, were rated by a taste panel as being 80 and 400 times sweeter resp. than a 2% sucrose solution Synthetic I (R = H, R1 = Me) showed a reduced sweetness intensity compared to I (R = Ac, R1 = Me) and (+)-dihydroquercetin was devoid of sweetness. I represent a new class of potentially noncaloric and noncariogenic intense sweeteners. I (R = Ac, R1 = Me) was prepared from acetophenone and benzaldehyde components in 5 steps. I (R = H, R1 = Me) was obtained from hesperetin by ring cleavage with PhCH2Cl, epoxidation and ring closure.

Journal of Medicinal Chemistry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Product Details of C16H14O6.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Sun, Dianqing’s team published research in ChemMedChem in 7 | CAS: 69097-99-0

ChemMedChem published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C65H82N2O18S2, Quality Control of 69097-99-0.

Sun, Dianqing published the artcileEvaluation of Flavonoid and Resveratrol Chemical Libraries Reveals Abyssinone II as a Promising Antibacterial Lead, Quality Control of 69097-99-0, the publication is ChemMedChem (2012), 7(9), 1541-1545, database is CAplus and MEDLINE.

As part of our ongoing effort to discover novel antitubercular and antibacterial agents and to exploit natural products as scaffolds for chem. diversity, we have been interested in following up emerging and underexplored naturally occurring compounds showing good antimicrobial activities. In this regard, natural phytochems. are actively being pursued for their antibacterial properties. We subsequently screened the collated flavonoid and resveratrol library against M. tuberculosis and a panel of Gram-pos. and Gram-neg. bacterial pathogens, including Enterococcus faecalis, S. aureus, S. pneumoniae, Klebsiella pneumoniae, Acine-tobacter baumannii, Escherichia co/i, and P. aeruginosa. In conclusion, the systematic screening of a focused flavonoid and resveratrol library led to the identification of abyssinone II as an anti-Gram-pos. agent that could potentially have a multitargeted mode of action, resulting from its ability to target the bacterial membrane. Such agents are increasingly becoming attractive therapeutic options owing to their potent actions, likely multitarget effects and limited potential for resistance development. The characterization of abyssinone II as a membrane-targeting mol. therefore makes it a promising natural product lead, ideal for further medicinal chem. optimization to identify advanced exptl. candidates with antimicrobial therapeutic potential.

ChemMedChem published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C65H82N2O18S2, Quality Control of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Arthur, H. R.’s team published research in Journal of the Chemical Society in | CAS: 69097-99-0

Journal of the Chemical Society published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Synthetic Route of 69097-99-0.

Arthur, H. R. published the artcileExamination of the Rutaceae of Hong Kong. I. Flavonold glycosides from Zanthoxylum species and the occurrence of optically active hesperetin, Synthetic Route of 69097-99-0, the publication is Journal of the Chemical Society (1956), 632-5, database is CAplus.

The barks of Zanthoxylum species of Hong Kong contained hesperidin (I) and diosmin (II). Hydrolysis of I yielded a mixture of (±)- (III) and (-)-hesperetin (IV) from which pure III and IV were isolated. III and IV were characterized, and IV was racemized. III was converted into diosmetin (V) with N-bromosuccinimide. It was coneluded that I was a β-7-rutinoside of IV. Dried bark (400) g.) of Z. avicennae extracted with refluxing MeOH; and the extract concentrated gave 2.4 g. solids; the filtrate on further concentration yielded 1.5 g. brown crystals. The first crop extracted with light petroleum and then with MeOH and the residue crystallized gave II hydrate, m. 280° (decomposition) (from 50% aqueous C5H5N). The 2nd crop similarly treated yielded I hydrate, m. 260° (decomposition), [α]D27 -88.2° (c 1.24, C5H5N), and some more II hydrate. II (5 g.) left 4 days at room temperature with Ac2O-C5H5N, and the product crystallized from alc. and refluxed 2 hrs. with 5 ml. H2SO4 and 95 ml. alc. gave V, m. 253.0-4.5° (from alc.); triacetate, m. 189-91°; both compounds gave a red test with Mg-HCl-MeOH. V was also prepared from the hydrolysis of II in (CH2OH)2 by the method used for the hydrolysis of I. I (10 g.) refluxed 2 hrs. with 6% NaOH yielded isoferulic acid, m. 228-9°, pos. test with FeCl3; acetate, m. 204-5°. I (5 g.) treated at room temperature with Ac2O-C5H5N gave the acetate, C44H50O23, m. 176-9° (from alc.). I (5 g.) and 100 ml. (CH2OH)2 containing 5 ml. concentrated H2SO4 treated 40 min. in the H2O bath gave 1.8 g. of a mixture of III and IV, m. 224-6°, [α]D26 -16.9° (c 1.42, EtOH). I (4 g.), hydrolyzed by refluxing in dilute H2SO4 20 hrs., gave a mixture of III and IV, and from the filtrate glucose and rhamnose were isolated and identiffed as their osazones. The mixture (20 g.) of III and IV fractionally crystallized from EtOH by the triangular scheme gave 2.2 g. III as hexagonal prisms, m. 226-8°, [α]D27 0.0° (c 1.56, EtOH), and 2.5 g. IV as the more-soluble fraction, triangular plates, m. 216-18°, [α]D27 -37.6° (c 1.80, EtOH). The following III derivatives were prepared: 4′,7-di-Me ether, m. 132-3°; oxime, m. 227-8° (decomposition); triacetate, m. 139-41°. IV derivatives 4′,7-di-Me ether, m. 149-51° [α]D28 -35.6° (c 1.04, CHCl3); oxime, m. 219-20° (decomposition), [α]D27 -16.1° (c 0.40, EtOH); triacetate, m. 130-2°, [α]D26 21.1° (c 1.28, CHCl3). III and IV and their derivatives gave a red solution with Mg-HCl-MeOH. IV (0.4 g.) in 5 ml. (CH2OH)2 heated 2 hrs. at 250-60° in a sealed tube gave 0.1 g. III. Solutions of IV left 3 days in EtOH-NaOH or Et-OH-HCl did not racemize. III triacetate (0.9 g.), 0.45 g. N-bromosuccinimide, and 0.05 g. Bz2O2 heated 1 hr., 0.3 g. more N-bromosuccinimide added, the succinimide recovered the next morning, the filtrate concentrated, and the residue washed with hot H2O and crystallized gave 0.08 g. V, m. and mixed m.p. 250-3°. The dried bark of Z. cuspidatum gave I hydrate. II was isolated from the root bark of Z. nitidum. I and II were not isolated from the bark of the last species.

Journal of the Chemical Society published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Synthetic Route of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Wegener, Michael’s team published research in Chemistry – A European Journal in 21 | CAS: 27943-46-0

Chemistry – A European Journal published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C5H6N2O2, SDS of cas: 27943-46-0.

Wegener, Michael published the artcileSilver-Free Activation of Ligated Gold(I) Chlorides: The Use of [Me3NB12Cl11] as a Weakly Coordinating Anion in Homogeneous Gold Catalysis, SDS of cas: 27943-46-0, the publication is Chemistry – A European Journal (2015), 21(3), 1328-1336, database is CAplus and MEDLINE.

Phosphane and N-heterocyclic carbene ligated gold(I) chlorides can be effectively activated by Na[Me3NB12Cl11] under silver-free conditions. This activation method with a weakly coordinating closo-dodecaborate anion was shown to be suitable for a large variety of reactions known to be catalyzed by homogeneous gold species, ranging from carbocyclization to heterocyclization. Addnl., the capability of Na[Me3NB12Cl11] in a previously unknown conversion of 5-silyloxy-1,6-allenynes was demonstrated. The synthesis of the target compounds was achieved using sodium undecachloro(methanamine)dodecaborate as anion source and (triphenylphosphine)gold chloride, [[(1,1′-biphenyl]-2-yl)bis(1,1-dimethylethyl)phosphine](chloro)gold [Au(JohnPhos)cl], [μ-Bis(diphenylphosphino)methane]dichlorodigold, [1,3-Bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene](chloro)gold as catalysts.

Chemistry – A European Journal published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C5H6N2O2, SDS of cas: 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Trujillo, John I.’s team published research in Bioorganic & Medicinal Chemistry Letters in 21 | CAS: 624734-19-6

Bioorganic & Medicinal Chemistry Letters published new progress about 624734-19-6. 624734-19-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Fluoride,Ketone, name is 3-Fluorodihydro-2H-pyran-4(3H)-one, and the molecular formula is C12H14O2, Recommanded Product: 3-Fluorodihydro-2H-pyran-4(3H)-one.

Trujillo, John I. published the artcileDesign and synthesis of novel CCR2 antagonists: investigation of non-aryl/heteroaryl binding motifs, Recommanded Product: 3-Fluorodihydro-2H-pyran-4(3H)-one, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(6), 1827-1831, database is CAplus and MEDLINE.

This report describes the design and synthesis of a series of CCR2 antagonists incorporating novel non-aryl/heteroaryl RHS (right hand side) motifs e. g., I. Previous SAR in the area has suggested an aryl/heteroaryl substituent as a necessary structural feature for binding to the CCR2 receptor. Herein we describe the SAR with regards to potency (binding to hCCR2), dofetilide activity and metabolic stability (in vitro HLM) for this series. The resulting outcome was the identification of compounds with excellent properties for the investigation of the role of CCR2 in disease.

Bioorganic & Medicinal Chemistry Letters published new progress about 624734-19-6. 624734-19-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Fluoride,Ketone, name is 3-Fluorodihydro-2H-pyran-4(3H)-one, and the molecular formula is C12H14O2, Recommanded Product: 3-Fluorodihydro-2H-pyran-4(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Hauck, Zane Z.’s team published research in Rapid Communications in Mass Spectrometry in 30 | CAS: 267244-08-6

Rapid Communications in Mass Spectrometry published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C21H24O8, Recommanded Product: (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid.

Hauck, Zane Z. published the artcileDetermination of bisphenol A-glucuronide in human urine using ultrahigh-pressure liquid chromatography/tandem mass spectrometry, Recommanded Product: (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, the publication is Rapid Communications in Mass Spectrometry (2016), 30(3), 400-406, database is CAplus and MEDLINE.

Rationale : Used widely as a plasticizer and as a monomer for plastics, bisphenol A (BPA) is under investigation as a possible endocrine disrupter. As an indication of systemic exposure, a fast and accurate assay was developed for the major BPA metabolite in human urine, BPA-monoglucuronide (BPA-G), using ultraHPLC/tandem mass spectrometry (UHPLC/MS/MS). Methods : Urine samples were prepared using solid-phase mixed-mode reversed-phase/anion-exchange extraction BPA-G was measured using UHPLC/MS/MS with an amide UHPLC column interfaced to a triple-quadrupole mass spectrometer equipped with neg. ion electrospray, collision-induced dissociation and selected reaction monitoring. [13C12]-BPA-G was used as a surrogate standard Results : By measuring the glucuronide metabolite of BPA, potential interference due to BPA contamination from containers, solvents, pipet, etc., was avoided. The standard curve had a linear regression coefficient of 0.999, and the intra- and inter-assay variations were less than 10%. The assay was validated according to FDA guidelines. Conclusions : A fast, accurate, and highly selective method for the determination of BPA-G in human urine was developed and validated using UHPLC/MS/MS. This method is suitable for assessing human exposure to BPA. Copyright © 2016 John Wiley & Sons, Ltd.

Rapid Communications in Mass Spectrometry published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C21H24O8, Recommanded Product: (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Liu, Yangbin’s team published research in Chemical Communications (Cambridge, United Kingdom) in 52 | CAS: 27943-46-0

Chemical Communications (Cambridge, United Kingdom) published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Synthetic Route of 27943-46-0.

Liu, Yangbin published the artcileEnantioselective construction of branched 1,3-dienyl substituted quaternary carbon stereocenters by asymmetric allenyl Claisen rearrangement, Synthetic Route of 27943-46-0, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(80), 11963-11966, database is CAplus and MEDLINE.

The availability of enantiomerically enriched 1,3-dienyl substituted quaternary stereocenters is highly valuable for the synthesis of complex natural compounds Despite great advances in the area of construction of alkenyl-substituted types, a general, practical catalytic system that works for enantioselective formation of 1,3-diene derivatives still remains to be developed. Herein, we disclose the first asym. Claisen rearrangement of allenyl vinyl ethers to access optically active β-ketoesters, containing branched 1,3-butadienyl substituted stereocenters. A variety of substrates bearing a range of useful functional groups were well tolerated, thus affording the corresponding products with excellent enantioselectivities (up to 99% ee) and high yields (up to 91%).

Chemical Communications (Cambridge, United Kingdom) published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Synthetic Route of 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Liu, Yuan-yue’s team published research in Chinese Journal of Integrative Medicine in 26 | CAS: 69097-99-0

Chinese Journal of Integrative Medicine published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Liu, Yuan-yue published the artcileStudy on Mechanism of Chaihu Shugan Powder for Treating Depression Based on Network Pharmacology, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, the publication is Chinese Journal of Integrative Medicine (2020), 26(12), 921-928, database is CAplus and MEDLINE.

To analyze the effective components of Chinese medicine (CM) contained in Chaihu Shugan Powder (CSP) in the treatment of depressive disorders and to predict its anti-depressant mechanism by network pharmacol. Absorption, distribution, metabolism, excretion, and toxicity calculation method was used to screen the active components of CSP. Traditional Chinese Medicine System Pharmacol. Database Anal. Platform and text mining tool (GoPuMed database) were used to predict and screen the active ingredients of CSP and anti-depressive targets. Through Genetic Association Database, Therapeutic Target Database, and PharmGkb database targets for depression were obtained. Cytoscape3.2.1 software was used to establish a network map of the active ingredients-targets of CSP, and to analyze gene function and metabolic pathways through Database for Annotation, Visualization and Integrated Discovery and the Omicshare database. The 121 active ingredients and 15 depression-related targets which were screened from the database can exert antidepressant effects by improving the neural plasticity, growth, transfer condition and gene expression of neuronal cell, and the raise of the expression of gap junction protein. The 15 targets passed 14 metabolic pathways, mainly involved in the regulation of neurotransmitters (5-hydroxytryptamine, dopamine and epinephrine), inflammatory mediator regulation of TRP channels, calcium signaling pathway, cyclic adenosine monophosphate signaling pathway and neuroactive ligand-receptor interaction and other signal channels to exert anti-depressant effects. This article reveals the possible mechanism of CSP in the treatment of depression through network pharmacol. research, and lays a foundation for further target studies.

Chinese Journal of Integrative Medicine published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Application of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics