Month: November 2022

Smith, Edward H. published the artcileCoupling of Alkynyllithiums to 1,3-Diynes by Reaction with Dichlorobis(triphenylphosphine)nickel(II) in the Presence of Triphenylphosphine and Guanidine or Amidine Bases, Application of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Organometallics (1994), 13(12), 5169-72, database is CAplus.

Reaction of alkynyllithiums with NiCl₂(PPh₃)₂ and 2L [L = PPh₃, tetramethylguanidine, 1,8-diazabicyclo[5.4.0]undec-7-ene, ArN:CMeNMe₂, or ArN:C(NMe₂)NMe₂ (Ar = aryl group)] at low temperatures in THF resulted in moderate to good yields of the homocoupled products, 1,3-diynes. Experiments on cross-coupling suggested that the 1,3-diynes are produced by reductive elimination from intermediate dialkynylnickel species.

Organometallics published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C7H8O3, Application of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Allan, R. D. published the artcileFlavanone quinones from Cyperus species, Related Products of tetrahydropyran, the publication is Tetrahedron Letters (1973), 7-8, database is CAplus.

The flavonone quinones remerin, breverin, and scaberin (I R = R1 = H; R or R1 = Me or H; R1 = Me, resp.) were isolated from Remeria maritima, C. brevibracteatus, an C. scaber, resp. Methylation of (±)-hesperetin (II, R = H) gave II (R = Me) which on oxidation gave I (R = R1 = H).

Tetrahedron Letters published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Related Products of tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Bowden, Kenneth published the artcileThe synthesis of some compounds related to muscarine, SDS of cas: 27943-46-0, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1978), 1493-504, database is CAplus.

New compounds related to muscarine (I) were prepared by cyclization of aminoacetylenic glycols, themselves prepared by condensation of novel aminoacetaldehyde hemiacetal salts with alkynol derivatives E.g., Me₂N⁺HCH₂CH(OH)(OEt) Cl^– with PhCH₂OCMe₂CCH gave 13-16% PhCH₂OCMe₂CCCH(OH)CH₂NMe₂, which with HgSO₄/H₂SO₄ gave 15% THF derivative II.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, SDS of cas: 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Gounden, Verena published the artcileA pilot study: Relationship between Bisphenol A, Bisphenol A glucuronide and sex steroid hormone levels in cord blood in A South African population, Product Details of C21H24O8, the publication is Reproductive Toxicology (2021), 83-89, database is CAplus and MEDLINE.

Exposure to Bisphenol A (BPA) during early development particularly in- utero has been linked to a wide range of pathol. The aim of this study was to examine the relationship of BPA and its naturally occurring metabolite BPA-glucuronide (BPA-g) with sex steroid hormone levels in South African mother-child pairs. Third-trimester serum maternal samples and matching cord blood samples were analyzed for BPA, BPA-g and nine sex steroid hormones using liquid chromatog. tandem mass spectrometry (LC-MS/MS). Sixty maternal and child pairs were analyzed. Rank correlation demonstrated a significant pos. relationship between cord blood estradiol and cord blood BPA (p = 0.002) and maternal BPA levels (p = 0.02) resp. Cord blood testosterone from male infants showed a neg. Spearman’s correlation (r = -0.5, p = 0.02) with maternal BPA-g. There was no statistical difference in total testosterone levels in cord blood from male and female infants. The findings of the current study indicate a significant relationship between some key sex steroid hormones namely testosterone, dihydrotestosterone and estradiol and fetal exposure BPA.

Reproductive Toxicology published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C21H24O8, Product Details of C21H24O8.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Cui, Lu published the artcileDiscovering New Acetylcholinesterase Inhibitors by Mining the Buzhongyiqi Decoction Recipe Data, Synthetic Route of 69097-99-0, the publication is Journal of Chemical Information and Modeling (2015), 55(11), 2455-2463, database is CAplus and MEDLINE.

Myasthenia gravis (MG) is a neuromuscular disease that is conventionally treated with acetylcholinesterase (AChE) inhibitors, which may not fully remove the symptom for many reasons. When AChE inhibitors do not work, Chinese patients turn to Chinese medicine, such as the Buzhongyiqi decoction (BD), to treat MG. By elucidating the relations between the herbs of the Buzhongyiqi decoction recipe and AChE inhibitors with structure-based and ligand-based drug design methods and chemoinformatics approaches, the authors have found the key active components of BD. Using these key active components as templates, the authors have discovered five new AChE inhibitors through virtual screening of a com. compound library. The new AChE inhibitors have been confirmed with Ellman assays. This study demonstrates that lead identification can be inspired by elucidating Chinese medicine. Since BD is a mixture, further studies against other drug targets are needed.

Journal of Chemical Information and Modeling published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Synthetic Route of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Xu, Jing published the artcilePolyphenols from acorn leaves (Quercus liaotungensis) protect pancreatic beta cells and their inhibitory activity against a-glucosidase and protein tyrosine phosphatase 1B, Application In Synthesis of 69097-99-0, the publication is Molecules (2018), 23(9), 2167/1-2167/12, database is CAplus and MEDLINE.

Acorn leaves, which possess potential pharmacol. effects, are traditionally consumed as food in China. Phytochem. investigations of acorn leaves yielded one new and 25 known polyphenols, and their structures were identified by extensive spectroscopic anal. Three antidiabetes assays were conducted. Compound 2 considerably increased the survival of pancreatic beta cells by reducing the production of reactive oxygen species and enhancing the activities of superoxide dismutase, catalase, and glutathione in MIN6 cells damaged by H2O2. The preliminary mechanism by which compound 2 protects pancreatic beta cells was through the nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 HO-1 pathway. Most of the tested isolates showed strong inhibitory activity against a-glucosidase and protein tyrosine phosphatase 1B. The IC50 values of most compounds were much lower than those of the pos. control. The results suggest that polyphenols from acorn leaves are potential functional food ingredients that can be used as antidiabetic agents.

Molecules published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C8H5F3N4, Application In Synthesis of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Han, Chao published the artcileMetal ion-improved complexation countercurrent chromatography for enantioseparation of dihydroflavone enantiomers, HPLC of Formula: 69097-99-0, the publication is Journal of Chromatography A (2018), 1-9, database is CAplus and MEDLINE.

Cu(II) ion was selected as an additive to improve the enantioseparation efficiency of three dihydroflavone enantiomers in high-speed counter-current chromatog. (HSCCC), using hydroxypropyl-β-cyclodextrin (HP-β-CyD) as the chiral selector. The influences of important parameters, including the metal ion, the concentrations of HP-β-CyD and the Cu(II) ion, and the sample size were investigated. Under optimal conditions, three dihydroflavone enantiomers, including (±)-hesperetin, (±)-naringenin, and (±)-farrerol, were successfully enantiosepd. The chiral recognition mechanism was investigated. The enantioseparation was attributed to the different thermodn. stabilities of the binary complexes of HP-β-CyD and (±)-hesperetin, and Cu(II) ion could enhance this difference by forming ternary complexes with the binary complexes. This Cu(II) ion-improved complexation HSCCC system exhibited improved performance for chiral separation, and therefore it has great application potential in the preparative enantioseparation of other compounds with similar skeletons.

Journal of Chromatography A published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, HPLC of Formula: 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Cheng, Cheng published the artcileBisphenol A Sensors on Polyimide Fabricated by Laser Direct Writing for Onsite River Water Monitoring at Attomolar Concentration, Application of (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, the publication is ACS Applied Materials & Interfaces (2016), 8(28), 17784-17792, database is CAplus and MEDLINE.

This work presents an aptamer-based, highly sensitive and specific sensor for atto- to femtomolar level detection of bisphenol A (BPA). Because of its widespread use in numerous products, BPA enters surface water from effluent discharges during its manufacture, use, and from waste landfill sites throughout the world. On-site measurement of BPA concentrations in water is important for evaluating compliance with water quality standards or environmental risk levels of the harmful compound in the environment. The sensor in this work is porous, conducting, interdigitated electrodes that are formed by laser-induced carbonization of flexible polyimide sheets. BPA-specific aptamer is immobilized on the electrodes as the probe, and its binding with BPA at the electrode surface is detected by capacitive sensing. The binding process is aided by a.c. electroosmotic effect that accelerates the transport of BPA mols. to the nanoporous graphene-like structured electrodes. The sensor achieved a limit of detection of 58.28 aM with a response time of 20 s. The sensor is further applied for recovery anal. of BPA spiked in surface water. This work provides an affordable platform for highly sensitive, real time, and field-deployable BPA surveillance critical to the evaluation of the ecol. impact of BPA exposure.

ACS Applied Materials & Interfaces published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C21H24O8, Application of (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Teeguarden, Justin G. published the artcileEvaluation of Oral and Intravenous Route Pharmacokinetics, Plasma Protein Binding, and Uterine Tissue Dose Metrics of Bisphenol A: A Physiologically Based Pharmacokinetic Approach, HPLC of Formula: 267244-08-6, the publication is Toxicological Sciences (2005), 85(2), 823-838, database is CAplus and MEDLINE.

Bisphenol A (BPA) is a weakly estrogenic monomer used in the production of polycarbonate plastic and epoxy resins, both of which are used in food contact and other applications. A physiol. based pharmacokinetic (PBPK) model of BPA pharmacokinetics in rats and humans was developed to provide a physiol. context in which the processes controlling BPA pharmacokinetics (e.g., plasma protein binding, enterohepatic recirculation of the glucuronide [BPAG]) could be incorporated. A uterine tissue compartment was included to allow the correlation of simulated estrogen receptor (ER) binding of BPA with increases in uterine wet weight (UWW) in rats. I.v.- and oral-route blood kinetics of BPA in rats and oral-route plasma and urinary elimination kinetics in humans were well described by the model. Simulations of rat oral-route BPAG pharmacokinetics were less exact, most likely the result of oversimplification of the GI tract compartment. Comparison of metabolic clearance rates derived from fitting rat i.v. and oral-route data implied that intestinal glucuronidation of BPA is significant. In rats, but not humans, terminal elimination rates were strongly influenced by enterohepatic recirculation. In the absence of BPA binding to plasma proteins, simulations showed high ER occupancy at doses without uterine effects. Restricting free BPA to the measured unbound amount demonstrated the importance of including plasma binding in BPA kinetic models: the modeled relationship between ER occupancy and UWW increases was consistent with expectations for a receptor-mediated response with low ER occupancy at doses with no response and increasing occupancy with larger increases in UWW.

Toxicological Sciences published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C6H8O6, HPLC of Formula: 267244-08-6.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Kikukawa, Kiyoshi published the artcileRegioselective hydrostannation of terminal acetylenes under transition metal catalysis, Application In Synthesis of 27943-46-0, the publication is Chemistry Letters (1988), 881-4, database is CAplus.

Rhodium complexes [RhClL₃, RhCl(CO)L₂ (L = PPh₃)], [RhCl(COD)]₂ (COD = 1,5-cyclooctadiene)] catalyze the hydrostannylation of terminal acetylenes, RCCH (R = Ph, Me₃Si, etc.) with Bu₃SnH to produce RC(SnBu₃):CH₂ selectively. Other transition metal complexes [MCl₂L₂ (M = Ni, Pd, Pt, Co)] are also active for the hydrostannylation, but with less selectivity.

Chemistry Letters published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Application In Synthesis of 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics