Month: November 2022

Qiu, Youai published the artcileStudies on [PtCl₂]- or [AuCl]-Catalyzed Cyclization of 1-(Indol-2-yl)-2,3-Allenols: The Effects of Water/Steric Hindrance and 1,2-Migration Selectivity, Recommanded Product: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Chemistry – A European Journal (2014), 20(33), 10314-10322, database is CAplus and MEDLINE.

The [PtCl₂]- or [AuCl]-catalyzed reaction of 1-(indol-2-yl)-2,3-allenols occurred smoothly at room temperature to afford a series of poly-substituted carbazoles efficiently. Compared with the [PtCl₂]-catalyzed process, the [AuCl]-catalyzed reaction represents a significant advance in terms of the scope and the selectivity. Selective 1,2-alkyl or aryl migration of the gold carbene intermediate was observed: compared with the Me group, the iso-Pr, cyclopropyl, cyclobutyl, and cyclohexyl groups migrate exclusively; the cyclopropyl group shifts selectively over the Et group; the 1,2-migration of a non-Me linear alkyl is faster than Me group; the Ph group migrates exclusively over Me or Et group. DFT calculations show that water makes the elimination of H₂O facile requiring a much lower energy and validates the migratory preferences of different alkyl or Ph groups observed

Chemistry – A European Journal published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Recommanded Product: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Karlsen, Steinar published the artcileNew syntheses of the bark beetle pheromones 2-methyl-6-methylene-7-octen-4-ol (ipsenol) and 2-methyl-6-methylene-2,7-octadien-4-ol (ipsdienol), Computed Properties of 27943-46-0, the publication is Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry (1976), B30(7), 664-8, database is CAplus.

H2C:CHC(:CH2)CH2CHO, obtained by thermal [3,3] sigmatropic rearrangement of CH2:C:CHCH2OCH:CH2, was treated with Me2CHCH2MgBr or Me2C:CHMgBr to give the Ips pheromone CH2:CHC(:CH2)CH2CH(OH)CHCHMe2 (ipsenol) or CH2:CHC(:CH2)CH2CH(OH):CMe2 (ipsdienol), resp.

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Computed Properties of 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Nachman, Rebecca M. published the artcileSerial Free Bisphenol A and Bisphenol A Glucuronide Concentrations in Neonates, Computed Properties of 267244-08-6, the publication is Journal of Pediatrics (New York, NY, United States) (2015), 167(1), 64-69, database is CAplus and MEDLINE.

To determine the balance of metabolism of free bisphenol A (BPA) to the inactive conjugate, BPA glucuronide (BPAG), in neonates. Free BPA and BPAG concentrations were measured in 78 urine samples collected between Dec. 2012 and August 2013 from a cohort of 44 healthy full term (≥37 wk’ gestation) neonates at 2 intervals (3-6 days and 7-27 days of age). A questionnaire was administered at the time of sample collection. Neonates recruited into the study were born in an urban, tertiary care hospital. Only BPAG was detected in the urine samples; concentrations ranged from <0.1 μg/L to 11.21 μg/L (median: 0.27 μg/L). Free BPA concentrations were below the limit of quantification of 0.1 μg/L. Age, but not sex or type of diet, was significantly associated with urinary BPAG concentration (P = .002). Our results illustrate widespread BPA exposure in healthy full-term neonates and efficient conjugation of BPA to its readily excretable and biol. inactive form (BPAG) as early as 3 days of age. Factors other than type of diet may be important contributors to BPA exposure in neonates.

Journal of Pediatrics (New York, NY, United States) published new progress about 267244-08-6. 267244-08-6 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Chiral,Carboxylic acid,Benzene,Phenol,Alcohol,Ether,, name is (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)tetrahydro-2H-pyran-2-carboxylic acid, and the molecular formula is C21H24O8, Computed Properties of 267244-08-6.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Ficarra, Paola published the artcileDirect enantiomeric separation of flavanones by high performance liquid chromatography using various chiral stationary phases, Synthetic Route of 69097-99-0, the publication is Planta Medica (1995), 61(2), 171-6, database is CAplus and MEDLINE.

The performance of four chiral liquid chromatog. columns (Chiralcel OA, OJ, OC, OD) was studied with respect to the enantioseparation of flavanones and some derivatives The effect of mobile phase composition on the retention time and stereoselectivity was studied. A good enantioseparation (α up to 1.45) was achieved for most of the racemates. Further, the elution order of the enantiomers from the chiral stationary phases has been determined by using a CD based detection system.

Planta Medica published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Synthetic Route of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Nguyen, Sean S. published the artcileButenolide Synthesis from Functionalized Cyclopropenones, Synthetic Route of 27943-46-0, the publication is Organic Letters (2019), 21(21), 8695-8699, database is CAplus and MEDLINE.

A general method to synthesize substituted butenolides I (R¹ = Me, C₆H₅, 2-thiophenyl, etc.; R²,R³ = H,Me) from hydroxymethylcyclopropenones is reported. Functionalized cyclopropenones undergo ring-opening reactions with catalytic amounts of phosphine, forming reactive ketene ylides. These intermediates can be trapped by pendant hydroxy groups to afford target butenolide scaffolds. The reaction proceeds efficiently in diverse solvents and with low catalyst loadings. Importantly, the cyclization is tolerant of a broad range of functional groups, yielding a variety of α- and γ-substituted butenolides.

Organic Letters published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Synthetic Route of 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Visalli, Giuseppa published the artcileBergamot Juice Extract Inhibits Proliferation by Inducing Apoptosis in Human Colon Cancer Cells, Synthetic Route of 69097-99-0, the publication is Anti-Cancer Agents in Medicinal Chemistry (2014), 14(10), 1402-1413, database is CAplus and MEDLINE.

Colorectal cancer (CRC) is a leading cause of cancer mortality in the industrialized world, second to lung cancer. A lot of evidences highlight that a diet rich in fruits and vegetables may reduce the risk of some types of cancer including CRC. In this study we demonstrate that Citrus bergamia juice extracts (BJe) reduces CRC cell growth by multiple mechanisms. Low BJe concentrations inhibit MAPKs pathway and alter apoptosis-related proteins, that in turn induce cell cycle arrest and apoptosis in HT-29 cells. Instead, high concentrations of BJe induce oxidative stress causing DNA damage. Our study highlights the role of BJe as modulator of cell apoptosis in CRC cells and strengthens our previous hypothesis that the flavonoid fraction of bergamot juice may play a role as anti-cancer drug.

Anti-Cancer Agents in Medicinal Chemistry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C12H15ClO3, Synthetic Route of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Alexander, Cameron published the artcileSynthesis of a series of ethynyl-substituted triphenylmethanes, Formula: C10H16O2, the publication is Synthesis (1992), 735-7, database is CAplus.

Triphenylmethyl-substituted alkynyl monomers I (R = H, Me) and II, required as part of a study concerning conjugated polyradicals, were prepared in multistep processes. Thus, II was prepared from Ph₃CH in 3 steps involving Friedel-Crafts monoacetylation with AcCl, followed by Vilsmeier formylation to give β-chloro aldehyde III, and elimination by KOH in aqueous MeOH/THF.

Synthesis published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Formula: C10H16O2.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Barton, Derek H. R. published the artcileSynthesis of the insect molting hormone, ecdysone, and related compounds, Product Details of C10H16O2, the publication is Journal of the Chemical Society [Section] C: Organic (1970), 1584-91, database is CAplus and MEDLINE.

A relatively short synthesis of the insect molting hormone, ecdysone, and of its C-22 isomer is described, starting from ergosterol. A key step is the direct transformation of the 3α,5α-cycloergosta-7,22-dien-6-one into the 14α- and 14β-ergosta-2,7,22-trien-6-ones. Selective cis-hydroxylation of the 2-enes, followed by enol acetylation and oxidation with perphthalic acid afforded the 5α-ecdysone nucleus. Ozonolysis of the C-22 double bond gave (20S)-2β,3β-diacetoxy-20-formyl-14α-hydroxy-5α-pregn-7-en-6-one, to which the ecdysone side chain was attached in a known manner.

Journal of the Chemical Society [Section] C: Organic published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Product Details of C10H16O2.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Partridge, John J. published the artcileVitamin D3 metabolites. I. Synthesis of 25-hydroxycholesterol, SDS of cas: 27943-46-0, the publication is Helvetica Chimica Acta (1974), 57(3), 764-71, database is CAplus and MEDLINE.

25-Hydroxycholesterol (I) was prepared from stigmasterol in 7 steps. Key transformation included the ozonolysis-reduction of cyclostigmasterol Me ether to give the (hydroxymethyl)cyclopregnane II (R = HO), and the condensation of II (R = 4-MeC6H4SO3, iodo) with LiCCCMe2OR1 (R1 = tetrahydro-2H-pyran-2-yl) to give the cyclopregnyne III.

Helvetica Chimica Acta published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, SDS of cas: 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Nishino, Chikao published the artcileAntibacterial activity of flavonoids against Staphylococcus epidermidis, a skin bacterium, Related Products of tetrahydropyran, the publication is Agricultural and Biological Chemistry (1987), 51(1), 139-43, database is CAplus.

An investigation was carried out on Okinawan plants to find antibacterial compounds against a human skin bacterium, S. epidermidis, which causes acne vulgaris. A medicinal plant, Elaeagnus glabra, showed significant activity, and (-)-epigallocatechin (I) was isolated from the plant as an antibacterial constituent against the bacterium. Twenty-six flavonoids related to I were tested for antibacterial activity, galangin (II) being the most active species. Although a structure-activity study was attempted, no clear structural factor was deduced.

Agricultural and Biological Chemistry published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Related Products of tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics