Zhang, Zhi-Qing’s team published research in World Journal of Traditional Chinese Medicine in 7 | CAS: 69097-99-0

World Journal of Traditional Chinese Medicine published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C21H24O8, HPLC of Formula: 69097-99-0.

Zhang, Zhi-Qing published the artcileExploring the pharmacological mechanism of danhe granules against hyperlipidemia by means of network pharmacology and verified by preliminary experiments, HPLC of Formula: 69097-99-0, the publication is World Journal of Traditional Chinese Medicine (2021), 7(4), 436-444, database is CAplus.

This study explored the multicomponent, multitarget, and multipathway mechanism of Danhe granules(DG) against hyperlipidemia through network pharmacol. The relevant targets and pathways were verified by preliminary experiments The active components of DG were selected by TCMSP and TCMIP database, and the component-target network diagram was constructed by Cytoscape 3.7.1. The protein-protein interaction network of targets was constructed and core targets were screened out by STRING11.0 database. Metascape database and Cytoscape 3.7.1 were used to enrich the target and establish a hyperlipidemia model in Sprague-Dawley (SD) rats to detect blood lipid and oxidative stress indexes and observed pathol. changes of aorta by H and E staining. The results showed that a total of seven active components of DG were screened out, including quercetin, sitosterol, luteolin, kaempferol, etc. There were 127 corresponding targets, including AKT1, tumor necrosis factor, TP53, interleukin-6, RELA, vascular endothelial growth factor, superoxide dismutases, and catalase. It is mainly involved in biol. processes such as drug response, regulation of apoptosis, redox reaction, and lipid reaction. There were 573 signal pathways corresponding to the target, including HIF-1 signal pathway, TNF signal pathway, VEGF signal pathway, nonalcoholic fatty liver disease, etc. The experiment verified that DG can reduce the blood lipid of SD rats by regulating the process of oxidative stress. This study made a preliminary study on the pharmacol. mechanism of DG against hyperlipidemia and laid the foundation for the research and development of new drugs and subsequent in-depth research.

World Journal of Traditional Chinese Medicine published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C21H24O8, HPLC of Formula: 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Anselmi, Cecilia’s team published research in Journal of Agricultural and Food Chemistry in 40 | CAS: 27943-46-0

Journal of Agricultural and Food Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Category: tetrahydropyran.

Anselmi, Cecilia published the artcileOdor properties of some tetrahydropyranyl ethers, Category: tetrahydropyran, the publication is Journal of Agricultural and Food Chemistry (1992), 40(5), 853-6, database is CAplus.

Thirty-one tetrahydropyranyl derivatives of phenols, and alcs., were prepared with the aim of reproducing the floral note of hydroxycitronellal in compounds of easier and cheaper synthesis. Some of the derivatives, particularly those prepared from cis-4-methylcyclohexanol (I) and p-alkylphenols, present a floral character as the main note and could be used as detergent additives and in other products with pH greater than 7. This research also represents a contribution toward the understanding of the relationships between mol. structure and the odor of muguet. Thus, treating alcs., e.g. I with tetrahydro-2H-pyran (THP) and a catalytic amount of HCl or TsOH gave the THP ether of I which has a plesant floral odor.

Journal of Agricultural and Food Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Category: tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Brocato, Emanuela’s team published research in Tetrahedron Letters in 33 | CAS: 27943-46-0

Tetrahedron Letters published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Category: tetrahydropyran.

Brocato, Emanuela published the artcileA new palladium-catalyzed synthesis of 3-substituted 2-arylidene-2,3-dihydro-1H-inden-1-ones, Category: tetrahydropyran, the publication is Tetrahedron Letters (1992), 33(48), 7433-6, database is CAplus.

Sequential oxidative additions of 2-IC6H4CH2X (X = CO2Me, CO2CHMe2, CONEt2), carbon monoxide insertion, reductive coupling with HCCY (Y = Ph, 4-MeOC6H4), nucleophilic attack by the activated methylene group, and protonation with metal elimination afford the title compounds I in a one-pot catalytic process.

Tetrahedron Letters published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Category: tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Caccamese, Salvatore’s team published research in Journal of Chromatography A in 1076 | CAS: 69097-99-0

Journal of Chromatography A published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Safety of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Caccamese, Salvatore published the artcileHigh-performance liquid chromatographic separation and chiroptical properties of the enantiomers of naringenin and other flavanones, Safety of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, the publication is Journal of Chromatography A (2005), 1076(1-2), 155-162, database is CAplus and MEDLINE.

The HPLC enantiomeric separation of naringenin, eriodictyol, hesperetin and pinocembrin was accomplished in the normal-phase mode using two polysaccharide-derived chiral stationary phases (Chiralcel OD-H and Chiralpak AS-H) and various n-hexane/alc. mobile phases. The 3′,4′ substituents pattern affect the enantioselectivity of these phases. Single enantiomers of naringenin were isolated by semipreparative HPLC and their CD spectra were measured and related to the absolute configuration by the exciton-coupling method. Online coupling HPLC/spectropolarimeter afforded the CD sign of the eluted peaks at a single wavelength, and the complete CD spectra of the eluted enantiomers were obtained by trapping them in the spectropolarimeter cell through a switching valve.

Journal of Chromatography A published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Safety of 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Nelson, Ronald’s team published research in Chemical Science in 11 | CAS: 27943-46-0

Chemical Science published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Recommanded Product: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Nelson, Ronald published the artcileSkeletal diversity in Pt- and Au-catalyzed annulations of allenedienes: dissecting unconventional mechanistic pathways, Recommanded Product: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Chemical Science (2020), 11(16), 4209-4220, database is CAplus and MEDLINE.

Here, authors describe the discovery of unprecedented Pt or Au catalysts promoted annulation processes of 1,7-allenedienes, promoted by Pt or Au catalysts. These transformations revealed mechanistic pathways that had not been previously observed in reactions involving carbophilic catalysis. In particular, author have found that allenedienes bearing a silyl ether in the carbon tether connecting the diene and the allene divergently afford cyclopropane-embedded tricyclic derivatives, 6,6-fused bicarbocyclic products or 5,6-fused bicarbocyclic systems, depending on the type of Au or Pt catalyst used. Author have carried out exptl. and computational studies that shed light on the mechanistic reasons behind this rich and unusual skeletal divergence, and provide new lessons on the drastic influence of platinum ancillary ligands on the reaction outcome.

Chemical Science published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Recommanded Product: 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Thomas, Emmanuel’s team published research in European Journal of Medicinal Chemistry in 86 | CAS: 27943-46-0

European Journal of Medicinal Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C24H29N5O3, Related Products of tetrahydropyran.

Thomas, Emmanuel published the artcileSynthesis and preliminary biological evaluation of new antiproliferative aromatic analogues of 1α,25-dihydroxyvitamin D3, Related Products of tetrahydropyran, the publication is European Journal of Medicinal Chemistry (2014), 381-393, database is CAplus and MEDLINE.

In an effort to develop novel vitamin D3 analogs, a series of aromatic compounds was synthesized, using efficient Negishi cross coupling between alkenylzinc reagents of the C,D-ring moiety of vitamin D3, and various substituted aromatic halides as A-ring mimics. The study aimed at exploring the influence of the replacement of the original vitamin D3 diene by a styrene unit on the biol. activities. Potency in the induction of the differentiation of HL-60 cells for the lead compound I was 12 fold less important than calcitriol correlating with a weaker binding affinity for VDR.

European Journal of Medicinal Chemistry published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C24H29N5O3, Related Products of tetrahydropyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Claesson, Alf’s team published research in Acta Chemica Scandinavica (1947-1973) in 26 | CAS: 27943-46-0

Acta Chemica Scandinavica (1947-1973) published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Safety of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Claesson, Alf published the artcileAllenes and acetylenes. I. Formation of conjugated dienes on lithium aluminum hydride reduction of allenic tert-alcohols, Safety of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, the publication is Acta Chemica Scandinavica (1947-1973) (1972), 26(6), 2540-2, database is CAplus.

The cyclohexanol I was refluxed 20 min with LiAlH4 in Et2O to give 72% of the cyclohexanol II. II was refluxed with LiAlH4 in THF under N to give 75% 2-propenylidenecyclohexane (III). I was refluxed with LiAlH4 in THF under N to give 70% of III. Similar results were obtained for the reaction of IV with LiAlH4 in Et2O and THF. LiAlD4 reduction of II gave 2-propenylidenecyclohexane-2-d.

Acta Chemica Scandinavica (1947-1973) published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Safety of 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Wistuba, Dorothee’s team published research in Electrophoresis in 27 | CAS: 69097-99-0

Electrophoresis published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C15H14Cl2S2, Synthetic Route of 69097-99-0.

Wistuba, Dorothee published the artcileδ-Cyclodextrin as novel chiral probe for enantiomeric separation by electromigration methods, Synthetic Route of 69097-99-0, the publication is Electrophoresis (2006), 27(21), 4359-4363, database is CAplus and MEDLINE.

Native δ-CD was employed as chiral selector in CE and MEKC. To study the potential of the enantiodiscriminating properties of δ-CD, neg. charged 5-dimethylamino-1-naphthalene-sulfonyl (dansyl)-, 2,4-dinitrophenyl (DNP)- and FMOC-derivatives of several amino acids, , flava-nones and three pos. charged drugs were selected as testing samples. Enantioresoln. factors up to 4.82 were observed The results were compared with those achieved by the conventional running buffer additives α-, β- and γ-CDs. For several examples a steady increase of enantioresoln. with increasing degree of oligomerization was detected.

Electrophoresis published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C15H14Cl2S2, Synthetic Route of 69097-99-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Peil, Sebastian’s team published research in Journal of the American Chemical Society in 142 | CAS: 27943-46-0

Journal of the American Chemical Society published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Computed Properties of 27943-46-0.

Peil, Sebastian published the artcileHydrogenative Metathesis of Enynes via Piano-Stool Ruthenium Carbene Complexes Formed by Alkyne gem-Hydrogenation, Computed Properties of 27943-46-0, the publication is Journal of the American Chemical Society (2020), 142(43), 18541-18553, database is CAplus and MEDLINE.

The only recently discovered gem-hydrogenation of internal alkynes is a fundamentally new transformation, in which both H atoms of dihydrogen are transferred to the same C atom of a triple bond while the other position transforms into a discrete metal carbene complex. [Cp*RuCl]4 is presently the catalyst of choice: the resulting piano-stool ruthenium carbenes can engage a tethered alkene into either cyclopropanation or metathesis, and a prototypical example of such a reactive intermediate with an olefin ligated to the ruthenium center has been isolated and characterized by X-ray diffraction. It is the substitution pattern of the olefin that determines whether metathesis or cyclopropanation takes place: a systematic survey using alkenes of largely different character in combination with a computational study of the mechanism at the local coupled cluster level of theory allowed the preparative results to be sorted and an intuitive model with predictive power to be proposed. This model links the course of the reaction to the polarization of the double bond as well as to the stability of the secondary carbene complex formed, if metathesis were to take place. The first application of “hydrogenative metathesis” to the total synthesis of sinularones E and F concurred with this interpretation and allowed the proposed structure of these marine natural products to be confirmed. During this synthesis, it was found that gem-hydrogenation also provides opportunities for C-H functionalization. Moreover, silylated alkynes are shown to participate well in hydrogenative metathesis, which opens a new entry into valuable allylsilane building blocks. Crystallog. evidence suggests that the polarized [Ru-Cl] bond of the catalyst interacts with the neighboring R3Si group. Since attractive interligand Cl/R3Si contacts had already previously been invoked to explain the outcome of various ruthenium-catalyzed reactions, including trans-hydrosilylation, the exptl. confirmation provided herein has implications beyond the present case.

Journal of the American Chemical Society published new progress about 27943-46-0. 27943-46-0 belongs to tetrahydropyran, auxiliary class Tetrahydropyran,Alkynyl,Ether, name is 2-((2-Methylbut-3-yn-2-yl)oxy)tetrahydro-2H-pyran, and the molecular formula is C10H16O2, Computed Properties of 27943-46-0.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics

Gosav, Steluta’s team published research in Romanian Reports in Physics in 66 | CAS: 69097-99-0

Romanian Reports in Physics published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Product Details of C16H14O6.

Gosav, Steluta published the artcileMultivariate study of flavonoids active against Caco-2 colon carcinoma, Product Details of C16H14O6, the publication is Romanian Reports in Physics (2014), 66(2), 411-426, database is CAplus.

A multivariate study involving flavonoids with activity against human colon carcinoma Caco-2 is reported. The data set is composed of 26 flavonoids which can be separated, depending on their EC50 value i.e. the half maximal effective concentration, into active and less active compounds Our purpose was to transform the chem. structure of each compound into a set of numbers, and to correlate them with the biol. activity establishing a qual./quant. relationship between calculated mol. descriptors and antiproliferative activity. The geometries of the studied flavonoids were fully optimized employing the D. Functional Theory (DFT) with the hybrid functional B3LYP in conjunction with the 6-31G(d) basis set. For each optimized structure we computed a set of parameters (1,356 descriptors) which characterizes the mol. from structural, topol., steric, electronic, hydrophobic, etc. points of view. Using the Fisher’s weight and the correlation matrix, we reduced the number of descriptors from 1,356 to 15. Aiming to investigate which mol. descriptors would be more efficient in classifying flavonoid compounds according to their degree of anticancer activity, we applied two unsupervised learning methods, Principal Component Anal. (PCA) and Cluster Anal. (CA), and a supervised learning method, Stepwise Discriminant Anal. (SDA). Using the 15 selected descriptors as input, the PCA and SDA techniques supplied us with the following parameters as common relevant descriptors: C-16, EN, Mor08e, HATS8m. The reliability of the structure-activity relationship model is verified using the cross-validation technique, the percentage of correct classifications being of 92.31 %.

Romanian Reports in Physics published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C16H14O6, Product Details of C16H14O6.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics