Analytica Chimica Acta published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C15H10O2, Category: tetrahydropyran.
Si-Ahmed, Kahina published the artcileEvaluation of novel amylose and cellulose-based chiral stationary phases for the stereoisomer separation of flavanones by means of nano-liquid chromatography, Category: tetrahydropyran, the publication is Analytica Chimica Acta (2012), 85-94, database is CAplus and MEDLINE.
Three polysaccharide-based chiral stationary phases, Sepapak 1, Sepapak 2 and Sepapak 3 were evaluated in the present work for the stereoisomer separation of a group of 12 flavonoids including flavanones (flavanone, 4′-methoxyflavanone, 6-methoxyflavanone, 7-methoxyflavanone, 2′-hydroxyflavanone, 4′-hydroxyflavanone, 6-hydroxyflavanone, 7-hydroxyflavanone, hesperetin, naringenin) and flavanone glycosides (hesperidin, naringin) by nano-liquid chromatog. (nano-LC). The behavior of these chiral stationary phases (CSPs) towards the selected compounds was studied in capillary columns (100 μm internal diameter (internal diameter)) packed with the above mentioned CSPs using polar organic, reversed and normal elution modes. The influence of nature and composition of the mobile phase in terms of concentration and type of organic modifier, buffer type and water content (reversed phase elution mode) on the enantioresoln. (Rs), retention factor (k) and enantioselectivity (α) was evaluated. Sepapak 3 showed the best chromatog. results in terms of enantioresoln., enantioselectivity and short anal. time, employing a polar organic phase mode. A mixture of methanol/isopropanol (20/80, volume/volume) as mobile phase enabled the chiral separation of eight flavanones with enantioresoln. factor (Rs) in the range 1.15-4.18. The same analytes were also resolved employing reversed and normal phase modes with mixtures of methanol/water and hexane/ethanol at different ratios as mobile phases, resp. Loss in resolution for some compounds, broaden peaks and longer anal. times were observed with these last two chromatog. elution modes. Afterwards, a comparison with the other two CSPs was performed. A lower discrimination ability of Sepapak 1 and Sepapak 2 towards all the studied flavanoids was observed However, Sepapak 1 allowed the separation of naringenin enantiomers and naringin stereoisomers in polar organic phase which were not resolved with the other two CSPs.The nature of the chiral selector is of utmost importance for the resolution of the selected compounds Indeed, significant differences in enantioresoln. among the three tested CSPs were observed With regard to the only few data reported in the literature for the resolution of this class of compounds using polysaccharide-based CSPs by HPLC, the results obtained in this study by nano-LC showed higher (Rs) values and shorter anal. time.
Analytica Chimica Acta published new progress about 69097-99-0. 69097-99-0 belongs to tetrahydropyran, auxiliary class Other Aliphatic Heterocyclic,Benzene,Phenol,Ether,Inhibitor, name is 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one, and the molecular formula is C15H10O2, Category: tetrahydropyran.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydropyran,
Tetrahydropyran – an overview | ScienceDirect Topics