Chelliah, Mariappan V. et al. published their research in Journal of Medicinal Chemistry in 2007 | CAS: 13417-49-7

5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineReference of 13417-49-7

Heterotricyclic Himbacine Analogs as Potent, Orally Active Thrombin Receptor (Protease Activated Receptor-1) Antagonists was written by Chelliah, Mariappan V.;Chackalamannil, Samuel;Xia, Yan;Eagen, Keith;Clasby, Martin C.;Gao, Xiaobang;Greenlee, William;Ahn, Ho-Sam;Agans-Fantuzzi, Jacqueline;Boykow, George;Hsieh, Yunsheng;Bryant, Matthew;Palamanda, Jairam;Chan, Tze-Ming;Hesk, David;Chintala, Madhu. And the article was included in Journal of Medicinal Chemistry in 2007.Reference of 13417-49-7 This article mentions the following:

Pursuing our earlier efforts in the himbacine-based thrombin receptor antagonist area, we have synthesized a series of compounds that incorporate heteroatoms in the C-ring of the tricyclic motif. This effort has resulted in the identification of several potent heterocyclic analogs with excellent affinity for the thrombin receptor. Several of these compounds demonstrated robust inhibition of platelet aggregation in an ex vivo model in cynomolgus monkeys following oral administration. A detailed profile of I, a benchmark compound in this series, with a Ki of 4.3 nM, is presented. In the experiment, the researchers used many compounds, for example, 5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7Reference of 13417-49-7).

5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineReference of 13417-49-7

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics