Ruthenium(IV) porphyrin catalyzed phosphoramidation of aldehydes with phosphoryl azides as a nitrene source was written by Xiao, Wenbo;Zhou, Cong-Ying;Che, Chi-Ming. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2012.Synthetic Route of C6H8O2 This article mentions the following:
[RuIV(por)Cl2] (por = porphyrin dianion) can efficiently catalyze nitrene insertion into aldehyde C-H bonds with phosphoryl azides as a nitrene source to give N-acylphosphoramidates in good to high yields. Thus, treating 4-methylbenzaldehyde with 1.5 equiv of diphenylphosphoryl azide (DPPA) in the presence of 5 mol% [RuIV(TPP)Cl2] (TPP = meso-tetrakis(4-tolyl)porphyrin) in dichloroethane under inert atm. reflux conditions yielded the corresponding di-Ph (4-methylbenzoyl)phosphoramidite (2a) in 92% yield and with 100% substrate conversion. No reaction was observed in the absence of the ruthenium catalyst. The structure of 2a was determined by x-ray crystallog. In the experiment, the researchers used many compounds, for example, 5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7Synthetic Route of C6H8O2).
5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. The bismuth chloride-assisted cross-cyclization between homoallylic alcohols and epoxides provided various benzyl tetrahydropyran derivatives. The reaction afforded good yields of desired products and occurred under mild conditions.Synthetic Route of C6H8O2
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics