1,2-elimination of alcohol from homoallyl ethers under the influence of mixed metal bases was written by Margot, Christian;Rizzolio, Michele;Schlosser, Manfred. And the article was included in Tetrahedron in 1990.Application of 13417-49-7 This article mentions the following:
Lithium diisopropylamide in the presence of catalytic amounts of potassium tert-butoxide smoothly converts homoallyl or homobenzyl type ethers to dienes or styrenes. γ,δ-Unsaturated acetals give 1,3-dienyl ethers and 4-alkylidenetetrahydropyrans or dihydropyrans produce a variety of dienols. If there is a choice, the new double bond is formed with high trans selectivity while the configuration of existing double bonds is retained. The elimination mode is syn-periplanar and concerted, though E1cb like. In the experiment, the researchers used many compounds, for example, 5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7Application of 13417-49-7).
5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Application of 13417-49-7
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics