Gel permeation technique for characterizing chemically modified celluloses was written by Martin, Lawrence F.;Blouin, F. A.;Bertoniere, N. R.;Rowland, S. P.. And the article was included in Tappi in 1969.Quality Control of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate This article mentions the following:
Gel-permeation chromatog. is an effective method for obtaining quant. phys. measurements of changes produced in the structure of cellulose by chem. modification. The selection of stachyose, raffinose, maltose, and glucose as test solutes resulted in a simple linear relation between elution volume and hydrated mol. weight From this linear relation, extrapolation was made to the effective internal solvent volumes and limits of permeability of the samples. Values obtained were empirical measurements of the permeability of the cellulose samples, and the changes produced by chem. modifications agreed with the alteration of polymer structure. Cellulose crosslinked in the swollen state showed increased permeability because of its larger effective internal volume and limit of permeability. Crosslinking under conditions that minimize swelling increases the internal volume while causing a decrease in the limit of permeability. Monofunctional substitution increases the internal volume to the same extent as crosslinking in an unswollen state while increasing the limit of permeability. Microcrystalline wood cellulose had as large an internal volume as decrystd. cotton cellulose, but a much higher mol.-weight limit of permeability. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Quality Control of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate).
(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. Quality Control of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics