Linchpin Construction of Unsymmetrical 1,4-Alkynediols was written by Taber, Douglass F.;Storck, Pierre H.. And the article was included in Journal of Organic Chemistry in 2002.Recommanded Product: 13417-49-7 This article mentions the following:
Unsym. 1,4-alkynediols such as I are prepared by the coupling of trimethylsilylacetylene with two different aldehydes or ketones. Lithiation of trimethylsilylacetylene followed by addition of one aldehyde or ketone generates a lithium alkoxide; treatment with methyllithium removes the trimethylsilyl protecting group to generate a alkynyllithium which can add to a second aldehyde or ketone to give 1,4-alkynediols after workup. The desilylation reaction occurs only in THF. Aldehydes are preferable to ketones as the substrates for the first addition reaction; substrates with groups sensitive to base, such as easily lithiated arenes, should be added last. I, prepared in 65% yield from trimethylsilyllithium, cyclopropanecarboxaldehyde, and a dihydrobenzofurancarboxaldehyde, is converted to the diketone II, a metabolite of a potent nonsteroidal antiinflammatory agent, in two steps by oxidation of I to a 1,4-alkynyldione followed by reduction of the triple bond with palladium and barium sulfate. In the experiment, the researchers used many compounds, for example, 5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7Recommanded Product: 13417-49-7).
5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Recommanded Product: 13417-49-7
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics