Thermal rearrangement of α-oxo-α,β-unsaturated azines to N-substituted pyrazoles was written by Albright, Thomas A.;Evans, Steven;Kim, Choong S.;Labaw, Clifford S.;Russiello, Andrea B.;Schweizer, Edward E.. And the article was included in Journal of Organic Chemistry in 1977.Recommanded Product: 13417-49-7 This article mentions the following:
Thermolysis of α-oxo-α,β,-unsaturated azines R1COCR2:NN:CR3CR4:CHR5 [R1 = Me, Ph, EtO; R2 = H, Me, Ph; R3 = H, Me, Ph, CH:CHC6H4R6-4 (R6 = H, Cl), CH2P+Ph3Br-; R4 = H, Me, Br; R3R4 = (CH2)n (n = 3,4); R5 = Me, Ph, Bz, C6H4Cl-4, 2-furyl; R4R5 = (CH2)n (n = 3, 4), (CH2)3O, CH2O(CH2)2] is an efficient and general route to α-pyrazolyl esters or ketones I. The azines were prepared by either the condensation of α-diketone monohydrazones RCOC(:NNH2)R (R = Ph, Me) with α,β-unsaturatedaldehydes and ketones R1COCR2:CHR3 [R1 = H, Me, Ph; R2 = H, Me, Bz; R1R2 = (CH2)n (n = 3, 4); R3 = Me, Ph, Bz, 2-furyl; R2R3 = (CH2)n (n = 3, 4), (CH2)3O, CH2O(CH2)2] or the Wittig olefination of the stabilized phosphoranes Ph3P+C-HC(CH2R7):NN:CHCO2Et (R7 = H, P+Ph3Br-) with aldehydes 4-R8C6H4CHO (R8 = H, Cl). In the experiment, the researchers used many compounds, for example, 5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7Recommanded Product: 13417-49-7).
5,6-Dihydro-2H-pyran-3-carbaldehyde (cas: 13417-49-7) belongs to tetrahydropyran derivatives. Tetrahydropyran is a useful synthetic intermediate. Tetrahydropyranyl (THP-) ethers derived from the reaction of alcohols and dihydropyran are common intermediates in organic synthesis. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineRecommanded Product: 13417-49-7
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics