(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. In organic synthesis, the 2-tetrahydropyranyl group is used as a protecting group for alcohols. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Quality Control of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate
Role of water in the polymorphic transitions of small carbohydrates was written by Mathlouthi, Mohamed;Benmessaoud, Ghazi;Roge, Barbara. And the article was included in Food Chemistry in 2012.Quality Control of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate This article mentions the following:
Crystallization of small carbohydrates (hexoses, alditols, and disaccharides) in solution or from the melt is known to provide different polymorphs mainly due to their affinity with water and their mol. flexibility. Food and pharmaceutical applications sometimes require the use of a specific polymorph especially for its compaction and compression properties. Different factors affect the process of crystallization and make the selection of a polymorph in a straightforward step difficult. As a general rule, the crystallization of the most stable form or the easiest to crystallize is achieved and a polymorphic transition follows. To achieve the transition and obtain the desired crystal form, the control of water activity is needed. Examples of polymorph transitions are described. It is particularly the case for α-D-glucose monohydrate-anhydrous transition and the conversion of β sorbitol to the most stable polymorph γ. Polymorphic transitions were controlled by recording the XRPD patterns of the polymorph submitted to controlled water activity and temperature conditions. The morphol. of crystals was also observed under microscope. FTIR spectra of the polymorphs obtained at different aw values were recorded as well as DSC thermograms. Water vapor sorption isotherms were established and the kinetics of water intake determined An attempt of interpretation of the role of water in polymorphic transitions is made. The flexibility of sorbitol enhanced in presence of water vapor when samples are submitted to humid air seems at the origin of conformation change which induces conformational polymorphism. A difference is noticed between α-D-glucose monohydrate and sorbitol polymorphic transitions due to the difference in their solubility curves (enantiotropic for glucose, monotropic for sorbitol). In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7Quality Control of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate).
(2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate (cas: 14431-43-7) belongs to tetrahydropyran derivatives. In organic synthesis, the 2-tetrahydropyranyl group is used as a protecting group for alcohols. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Quality Control of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol hydrate
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics