Synthesis of Bicyclic Tertiary α-Amino Acids was written by Strachan, Jon-Paul;Whitaker, Regina C.;Miller, Craig H.;Bhatti, Balwinder S.. And the article was included in Journal of Organic Chemistry in 2006.COA of Formula: C9H16O3 This article mentions the following:
Novel bicyclic α-amino acids, exo and endo-1-azabicyclo[2.2.1]heptane-2-carboxylic acid, 1-azabicyclo[2.2.1]heptane-7-carboxylic acid, and 1-azabicyclo[3.2.2]nonane-2-carboxylic acid were readily synthesized for the generation of neuronal nicotinic receptor ligands. Alkylation of glycine-derived Schiff bases, e.g. Ph2C:NCH2CO2Me, or nitroacetates with cyclic ether electrophiles, e.g. 3-(iodomethyl)tetrahydrofuran, followed by acid-induced ring opening and cyclization in NH4OH, allowed for the preparation of substantial quantities of the three tertiary bicyclic α-amino acids. In the experiment, the researchers used many compounds, for example, Ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate (cas: 103260-44-2COA of Formula: C9H16O3).
Ethyl 2-(tetrahydro-2H-pyran-4-yl)acetate (cas: 103260-44-2) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. COA of Formula: C9H16O3
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics