Solubility enhancement of BCS class ii drugs was written by Bhamare, V. G.;Joshi, R. R.;Amrutkar, R. D.. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2021.Product Details of 41340-25-4 This article mentions the following:
One of the major barriers in the development of oral dosage form is poor solubility Poor water solubility obstructs drug bioavailability and decreases its pharmaceutical development. Many drugs are in the pipeline to enhance solubility to formulate dosage form to be taken by the most preferred route of administration that is the oral route. Etodolac is nonsteroidal anti-inflammatory drug having a wide spectrum of activities but belongs to BCS class II. The attempt has been made in this work to improve solubility by forming ternary inclusion complexes of Etodolac with PVP K30 and 尾-Cyclodextrins. The ternary inclusion complexes were prepared by the phys. mixing method and kneading method. The prepared complexes were analyzed by different anal. techniques comprising differential scanning calorimetry, IR spectroscopy and solubility study. Special emphasis was given on the solubility evaluation of drugs and complexes. Based on observations and results, one can easily conclude about the usefulness of the complexation technique for the enhancement of solubility In the experiment, the researchers used many compounds, for example, 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4Product Details of 41340-25-4).
2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Product Details of 41340-25-4
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics