Safety evaluation of the food enzyme alpha-amylase from Cellulosimicrobium funkei strain AE-AMT was written by EFSA Panel on Food Contact Materials, Enzymes and Processing Aids;Lambre, Claude;Barat Baviera, Jose Manuel;Bolognesi, Claudia;Cocconcelli, Pier Sandro;Crebelli, Riccardo;Gott, David Michael;Grob, Konrad;Lampi, Evgenia;Mengelers, Marcel;Mortensen, Alicja;Riviere, Gilles;Steffensen, Inger-Lise;Tlustos, Christina;Van Loveren, Henk;Vernis, Laurence;Zorn, Holger;Andryszkiewicz, Magdalena;Gomes, Ana;Liu, Yi;Rainieri, Sandra;Chesson, Andrew. And the article was included in EFSA Journal in 2022.SDS of cas: 9004-53-9 This article mentions the following:
The food enzyme α-amylase (4-α-D-glucan glucanohydrolase; EC 3.2.1.1) is produced with the non-genetically modified Cellulosimicrobium funkei strain AE-AMT by Amano Enzyme Inc. The food enzyme is free from viable cells of the production organism. It is intended to be used in starch processing for maltotriose production Since residual amounts of total organic solids (TOS) are removed by purification steps applied during starch processing, the estimation of a dietary exposure is considered unnecessary. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level at the highest dose of 230 mg TOS/kg body weight (bw) per day. Similarity of the amino acid sequence of the food enzyme to those of known allergens was searched and nine matches were found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitization and elicitation reactions by dietary exposure cannot be excluded, but the likelihood is considered low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use. In the experiment, the researchers used many compounds, for example, Dextrin (cas: 9004-53-9SDS of cas: 9004-53-9).
Dextrin (cas: 9004-53-9) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. SDS of cas: 9004-53-9
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics