Dietary supplementation with okara and Bacillus coagulans lilac-01 improves hepatic lipid accumulation induced by cholic acids in rats was written by Lee, Yeonmi;Tanaka, Yasutake;Iwasaki, Wakana;Yokoyama, Fumika;Joe, Ga-Hyun;Tsuji, Misaki;Nose, Takuma;Tada, Koji;Hanai, Taketo;Hori, Shota;Shimizu, Hidehisa;Minamida, Kimiko;Miwa, Kazunori;Ishizuka, Satoshi. And the article was included in Journal of Functional Foods in 2022.Reference of 9004-53-9 This article mentions the following:
A dietary symbiotic supplement of okara, a byproduct of tofu manufacturing with Bacillus coagulans lilac-01 found to reduce secondary bile acid (BA) in a rat study and cholic acid (CA), a primary 12伪-hydroxylated (12伪OH) BA, induces lipid accumulation in rats. In this study, we investigated whether dietary supplementation of a synbiotic with okara and Bacillus coagulans lilac-01 improves CA-induced hepatic lipid accumulation. Male Wistar/ST rats (4 wk old) were fed with or without CA-supplementation combined with the synbiotic for 2 wk. The CA diet increased hepatic triglycerides and the synbiotic diet in combination with CA normalized liver triglyceride concentration accompanied by suppression of hepatic fatty acid synthase expression, enhancement of fecal triglyceride excretion, and increase in fecal non-12伪OH BA excretion. Dietary supplementation with the okara synbiotic ameliorated hepatic lipid accumulation probably by reducing de novo lipogenesis and enhancing fecal triglyceride excretion. In the experiment, the researchers used many compounds, for example, Dextrin (cas: 9004-53-9Reference of 9004-53-9).
Dextrin (cas: 9004-53-9) belongs to tetrahydropyran derivatives. Tetrahydropyran is a useful synthetic intermediate. Tetrahydropyranyl (THP-) ethers derived from the reaction of alcohols and dihydropyran are common intermediates in organic synthesis. The Prins reaction of homoallylic alcohols with aldehydes afforded an alternative method for the preparation of tetrahydropyrans.Reference of 9004-53-9
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics