Nguyen, Huu Tung et al. published their research in Archives of Pharmacal Research in 2011 | CAS: 112246-15-8

20(R)-Ginsenoside Rh2 (cas: 112246-15-8) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineSafety of 20(R)-Ginsenoside Rh2

Inhibitory effect of ginsenosides from steamed ginseng-leaves and flowers on the LPS-stimulated IL-12 production in bone marrow-derived dendritic cells was written by Nguyen, Huu Tung;Quang, Tran Hong;Son, Jeong-Hyun;Koo, Jung-Eun;Hong, Hye-Jin;Koh, Young-Sang;Song, Gyu Yong;Kim, Young Ho. And the article was included in Archives of Pharmacal Research in 2011.Safety of 20(R)-Ginsenoside Rh2 This article mentions the following:

Interleukin-12, a heterodimeric cytokine comprising p40 and p35 subunits, plays an essential role in the regulating the differentiation of Th cells, which establish and maximize the capabilities of the immune system. The aim of present study is to screen the effect of 21 ginsenosides from steamed ginseng-leaves and flowers on IL-12 production in bone marrow-derived dendritic cells induced by lipopolysaccharide. Noticeably, ginsenoside Rg6 and ginsenoside F4 exhibited particularly inhibitory effect on LPS-induced IL-12 production with the inhibition values of 80 and 82%; and ginsenoside ST1 , ginsenoside SL2 , ginsenoside SL3 , ginsenoside Rh3, ginsenoside Rk2, and ginsenoside Rs4 showed moderate effects with inhibition rates of 63, 65, 67, 68, 71, 73, and 67%, resp. These results warrant further studies concerning potential of saponin extracts of steamed ginseng-leaves and flowers for medicinal uses. In the experiment, the researchers used many compounds, for example, 20(R)-Ginsenoside Rh2 (cas: 112246-15-8Safety of 20(R)-Ginsenoside Rh2).

20(R)-Ginsenoside Rh2 (cas: 112246-15-8) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineSafety of 20(R)-Ginsenoside Rh2

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics