Ti-Catalyzed Diastereoselective Cyclopropanation of Carboxylic Derivatives with Terminal Olefins was written by Ni, Jiabin;Xia, Xiaowen;Zheng, Wei-Feng;Wang, Zhaobin. And the article was included in Journal of the American Chemical Society in 2022.Application of 5337-03-1 This article mentions the following:
Herein, a Ti-based catalyst can effectively promote the diastereoselective syntheses of cyclopropanols such as I [R = i-Pr, cyclopropyl, Bn, etc.] and cyclopropylamines such as II [R = Me, Et, CH2-2-naphthyl, etc.; R1 = Me, Et, cyclohexyl, etc.; R2 = Me, Et, Bn, etc.; R1R2 = (CH2)4, (CH2)7, (CH2)2O(CH2)2, etc.] from widely accessible carboxylic derivatives (acids, esters, amides) with terminal olefins was described. To the best of the authors’ knowledge, this method represented the first example of direct converting alkyl carboxylic acids into cyclopropanols. Distinct from conventional studies in Ti-mediated cyclopropanations with reactive alkyl Grignard reagents as nucleophiles or reductants, this protocol utilized Mg and Me2SiCl2 to turn over the Ti catalyst. This method exhibited broad substrate scope with good functional group compatibility and was amenable to late-stage synthetic manipulations of natural products and biol. active mols. In the experiment, the researchers used many compounds, for example, Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1Application of 5337-03-1).
Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Application of 5337-03-1
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics