Patel, Dilip K. et al. published their research in Latin American Journal of Pharmacy in 2021 | CAS: 41340-25-4

2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. The bismuth chloride-assisted cross-cyclization between homoallylic alcohols and epoxides provided various benzyl tetrahydropyran derivatives. The reaction afforded good yields of desired products and occurred under mild conditions.COA of Formula: C17H21NO3

Topical nanostructured lipid carrier (NLC) gel of etodolac: central composite design, optimization, in vitro skin penetration and dermatokinetic study was written by Patel, Dilip K.;Kesharwani, Roohi;Alhayyani, Sultan;Al-Abbasi, F. A.;Anwar, Firoz;Kumar, Vikas. And the article was included in Latin American Journal of Pharmacy in 2021.COA of Formula: C17H21NO3 This article mentions the following:

The objective of this investigation was to fabricate and evaluate a topical NLC based nanogel of etodolac. Topical nano formulation gel of drug was developed and its characterization variables were estimated The present work was optimized with the help of design expert software (central composite design). Etodolac encapsulated nanostructured lipid carrier were prepared by melt emulsification solidification at low temperature method (slight modification). Size distribution, efficiency of drug entrapment, ex vivo study, differential scanning calorimetry (DSC) of NLC dispersion. The optimized batch was evaluated for permeation data investigation, skin retention parameter by tape stripping technique and dermatokinetic study, pharmacodynamic studies of NLC gel encapsulated etodolac. The NLC formulations were developed in various size ranges from 224卤 to 613 nm. The etodolac entrapment efficacy and zeta potential of manufactured NLC were found to be 79.56 卤 1.04 to 86.04 卤 0.95% and -18.52 卤 0.58 to -22.80 卤 0.36 mV, resp. Dermatokinetic study in epidermis showed Cskin max 36.25 卤 2.64 cm2/h in case of NLC based nanogel while 18.25 卤 1.24 cm2/h in case of conventional gel suggesting that more penetration of etodolac from nano lipid based gel due to occlusive effect. In vivo study of etodolac nano gel is magnificent as compare to conventional gel that is able to decreases the edema beginning from 3rd hour and during time of study and offering sustaining anti-inflammatory action of etodolac NLC gel. In the experiment, the researchers used many compounds, for example, 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4COA of Formula: C17H21NO3).

2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. The bismuth chloride-assisted cross-cyclization between homoallylic alcohols and epoxides provided various benzyl tetrahydropyran derivatives. The reaction afforded good yields of desired products and occurred under mild conditions.COA of Formula: C17H21NO3

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Wang, Hongda et al. published their research in Analytical and Bioanalytical Chemistry in 2019 | CAS: 112246-15-8

20(R)-Ginsenoside Rh2 (cas: 112246-15-8) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. Pyran derivatives such as pyran flavonoids are biologically important. Monosaccharides containing six-membered rings are called pyranose.Synthetic Route of C36H62O8

In-depth profiling, characterization, and comparison of the ginsenosides among three different parts (the root, stem leaf, and flower bud) of Panax quinquefolius L. by ultra-high performance liquid chromatography/quadrupole-Orbitrap mass spectrometry was written by Wang, Hongda;Zhang, Chunxia;Zuo, Tiantian;Li, Weiwei;Jia, Li;Wang, Xiaoyan;Qian, Yuexin;Guo, Dean;Yang, Wenzhi. And the article was included in Analytical and Bioanalytical Chemistry in 2019.Synthetic Route of C36H62O8 This article mentions the following:

Despite Panax quinquefolius L. serving as a crucial source for food additives, healthcare products, and herbal medicines, unawareness of the metabolome differences among three parts (root, PQR; stem leaf, PQL; flower bud, PQF) seriously restricts its quality control. Ultra-high performance liquid chromatog./quadrupole-Orbitrap mass spectrometry (UHPLC/Q-Orbitrap-MS) was fully utilized to comprehensively identify and compare the ginsenoside compositions among PQR, PQL, and PQF. Metabolite profiling and characterization were performed by coupling reversed-phase UHPLC (a CSH C18 column) and improved untargeted data-dependent MS2 acquisition in the neg. mode. A novel vehicle, “Ginsenoside Sieve,” was proposed by developing fixed tolerance (卤 10 mDa), discrete mass defect filtering (MDF) based on the m/z features of 499 known ginsenosides, which assisted in the screening of 71 (from 3453 ions), 89 (from 6842), and 84 (from 7369) target precursor masses for PQR, PQL, and PQF, resp. The newly established data-dependent acquisition (DDA) approach exhibited 14% improvement in characterization of targeted components (using a PQL sample), and comparable performance in identifying the unknown, compared with conventional DDA. We could characterize 347 saponins (147 from PQR, 173 from PQL, and 195 from PQF), and 157 thereof not ever-isolated from the Panax genus. These potentially new saponins have 63 unknown masses. Subsequent untargeted metabolomics anal. unveiled 20 marker saponins, among which m-Rb1, Rb1, Ro, m-Rb2, and m-Rb1 isomer are the most important diagnostic for differentiating the three parts. Conclusively, the established improved DDA represents a potent ginsenoside characterization strategy, and the results obtained in this work would benefit better quality control of P. quinquefolius. In the experiment, the researchers used many compounds, for example, 20(R)-Ginsenoside Rh2 (cas: 112246-15-8Synthetic Route of C36H62O8).

20(R)-Ginsenoside Rh2 (cas: 112246-15-8) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. Pyran derivatives such as pyran flavonoids are biologically important. Monosaccharides containing six-membered rings are called pyranose.Synthetic Route of C36H62O8

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Saleh-Ghadimi, Sevda et al. published their research in Journal of the Science of Food and Agriculture in 2022 | CAS: 9004-53-9

Dextrin (cas: 9004-53-9) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Safety of Dextrin

Improvement of sleep by resistant dextrin prebiotic in type 2 diabetic women coincides with attenuation of metabolic endotoxemia: involvement of gut-brain axis was written by Saleh-Ghadimi, Sevda;Dehghan, Parvin;Sarmadi, Bahareh;Maleki, Parham. And the article was included in Journal of the Science of Food and Agriculture in 2022.Safety of Dextrin This article mentions the following:

Resistant dextrin, as a prebiotic and functional food, may possess favorable effects in type 2 diabetes. This study was conducted to assess whether supplementation with resistant dextrin can improve sleep and quality of life in obese type 2 diabetic women. In this randomized controlled trial, female obese type 2 diabetic patients (n = 76) were randomly assigned into intervention group (n = 38) and placebo group (n = 38), and received 10 g day-1 of resistant dextrin or maltodextrin for a period of 8 wk, resp. Sleep quality and quality of life (QOL) were assessed by Pittsburgh Sleep Quality Index (PSQI) and SF-36 health survey, resp. Fasting blood samples were driven to measure serum bacterial endotoxin, fasting blood sugar, glycosylated Hb (HbA1c), pro-inflammatory/anti-inflammatory biomarkers (IL-18, IL-6, IL-10, TNF-伪), and biomarkers of hypothalamic-pituitary-adrenal (HPA) axis function [tryptophan (TRP), adrenocorticotropic hormone (ACTH), kynurenine (KYN), cortisol]. Supplementation with resistant dextrin improved sleep (P < 0.001) and QOL (P < 0.001) significantly. It also caused a significant decrease in levels of endotoxin, HbA1c, IL-18, IL-6, TNF伪 and a significant increase in IL-10 levels. Significant and pos. correlations were found between endotoxin (r = 0.488, P = 0.003), IL-6 (r = 0.436, P = 0.008), IL-18 (r = 0.475, P = 0.003), cortisol (r = 0.545, P = 0.048), KYN/TRP (r = 0.527, P = 0.001), and PSQI scores. It is concluded that resistant dextrin improves sleep and QOL in obese women with type 2 diabetes. Its beneficial effects may be attributed in part to modulation of glycemia, metabolic endotoxemia and subsequently a decrease in biomarkers of inflammation and HPA axis activity. 2022 Society of Chem. Industry. In the experiment, the researchers used many compounds, for example, Dextrin (cas: 9004-53-9Safety of Dextrin).

Dextrin (cas: 9004-53-9) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Safety of Dextrin

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Wei, Lei et al. published their research in Journal of Organic Chemistry in 2021 | CAS: 5337-03-1

Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Synthetic Route of C6H10O3

Esterification of Carboxylic Acids with Aryl Halides via the Merger of Paired Electrolysis and Nickel Catalysis was written by Wei, Lei;Wang, Zhen-Hua;Jiao, Ke-Jin;Liu, Dong;Ma, Cong;Fang, Ping;Mei, Tian-Sheng. And the article was included in Journal of Organic Chemistry in 2021.Synthetic Route of C6H10O3 This article mentions the following:

Electrochem. has been successfully applied in metal catalysis to avoid the usage of chem. redox agents. This strategy proved to be a powerful approach to construct carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds. However, most of the developed methods are based on either anodic oxidation or cathodic reduction, in which a sacrificial reaction occurs at the counter electrode. Paired electrolysis merging with metal catalysis is underdeveloped, wherein both anodic and cathodic processes are taking place simultaneously. Herein, we demonstrated that by using esterification of carboxylic acids with aryl halides via paired electrolysis using nickel as the catalyst the resp. aryl esters were obtained in good to excellent yields at room temperature in an undivided electrochem. cell. In the experiment, the researchers used many compounds, for example, Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1Synthetic Route of C6H10O3).

Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Synthetic Route of C6H10O3

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

O’keefe, Sarah et al. published their research in Journal of Cell Science in 2021 | CAS: 11024-24-1

Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. The Prins reaction of homoallylic alcohols with aldehydes afforded an alternative method for the preparation of tetrahydropyrans.Quality Control of Digitonin

Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor was written by O’keefe, Sarah;Roboti, Peristera;Duah, Kwabena b.;Zong, Guanghui;Schneider, Hayden;Shi, Wei q.;High, Stephen. And the article was included in Journal of Cell Science in 2021.Quality Control of Digitonin This article mentions the following:

In order to produce proteins essential for their propagation, many pathogenic human viruses, including SARS-CoV-2, the causative agent of COVID-19 respiratory disease, commandeer host biosynthetic machineries and mechanisms. Three major structural proteins, the spike, envelope and membrane proteins, are amongst several SARS-CoV-2 components synthesized at the endoplasmic reticulum (ER) of infected human cells prior to the assembly of new viral particles. Hence, the inhibition of membrane protein synthesis at the ER is an attractive strategy for reducing the pathogenicity of SARS-CoV-2 and other obligate viral pathogens. Using an in vitro system, we demonstrate that the small mol. inhibitor ipomoeassin F (Ipom-F) potently blocks the Sec61-mediated ER membrane translocation and/or insertion of three therapeutic protein targets for SARS-CoV-2 infection; the viral spike and ORF8 proteins together with angiotensin-converting enzyme 2, the host cell plasma membrane receptor. Our findings highlight the potential for using ER protein translocation inhibitors such as Ipom-F as host-targeting, broad-spectrum antiviral agents. In the experiment, the researchers used many compounds, for example, Digitonin (cas: 11024-24-1Quality Control of Digitonin).

Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. The Prins reaction of homoallylic alcohols with aldehydes afforded an alternative method for the preparation of tetrahydropyrans.Quality Control of Digitonin

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Do, Thi Kieu Tien et al. published their research in Journal of Planar Chromatography–Modern TLC in 2022 | CAS: 17388-39-5

(4aR,5R,6S)-4a-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-4,4a,5,6-tetrahydropyrano[3,4-c]pyran-1(3H)-one (cas: 17388-39-5) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Br酶nsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Computed Properties of C16H22O10

Complementary developing solvents for simpler and more powerful routine analysis by high-performance thin-layer chromatography was written by Do, Thi Kieu Tien;Schmid, Marco;Trettin, Ilona;Hanni, Mona;Reich, Eike. And the article was included in Journal of Planar Chromatography–Modern TLC in 2022.Computed Properties of C16H22O10 This article mentions the following:

Because the separation power of an high-performance thin-layer chromatog. (HPTLC) plate is difficult to increase, method development in HPTLC commonly focuses on the optimization of resolution between selected zones and has, over the years, led to a plethora of similar developing solvents containing the same components in different ratios. Laboratories performing routine HPTLC anal. based on monographs prescribed by pharmacopoeias, thus, have to maintain numerous different methods, solvents, and standards In order to simplify and harmonize the routine anal. of many diverse samples, this paper presents an innovative approach based on the parallel use of three complementary developing solvents (CDS) featuring different polarity and selectivity. The graphical or computational combination of the resulting three fingerprints expands the chromatog. profile of complex samples. The power of the concept is illustrated with HPTLC fingerprints for identification of some herbal drugs, herbal products, and a poly-herbal formulation. Furthermore, the CDS is able to differentiate and identify individual compounds Thirty-one substances, including iridoids, coumarins and carbohydrates were exemplarily analyzed. All substances migrate to RF values between 0.2 and 0.8 in at least one of the developing solvents, and discrimination of the substance classes is well accomplished. As central element of an advanced HPTLC protocol for routine application and combined with further multidimensional data anal., this CDS could provide the basis for computational methods that are able to evaluate large sets of HPTLC data in the near future. In the experiment, the researchers used many compounds, for example, (4aR,5R,6S)-4a-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-4,4a,5,6-tetrahydropyrano[3,4-c]pyran-1(3H)-one (cas: 17388-39-5Computed Properties of C16H22O10).

(4aR,5R,6S)-4a-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-4,4a,5,6-tetrahydropyrano[3,4-c]pyran-1(3H)-one (cas: 17388-39-5) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Br酶nsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Computed Properties of C16H22O10

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Ni, Jiabin et al. published their research in Journal of the American Chemical Society in 2022 | CAS: 5337-03-1

Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Application of 5337-03-1

Ti-Catalyzed Diastereoselective Cyclopropanation of Carboxylic Derivatives with Terminal Olefins was written by Ni, Jiabin;Xia, Xiaowen;Zheng, Wei-Feng;Wang, Zhaobin. And the article was included in Journal of the American Chemical Society in 2022.Application of 5337-03-1 This article mentions the following:

Herein, a Ti-based catalyst can effectively promote the diastereoselective syntheses of cyclopropanols such as I [R = i-Pr, cyclopropyl, Bn, etc.] and cyclopropylamines such as II [R = Me, Et, CH2-2-naphthyl, etc.; R1 = Me, Et, cyclohexyl, etc.; R2 = Me, Et, Bn, etc.; R1R2 = (CH2)4, (CH2)7, (CH2)2O(CH2)2, etc.] from widely accessible carboxylic derivatives (acids, esters, amides) with terminal olefins was described. To the best of the authors’ knowledge, this method represented the first example of direct converting alkyl carboxylic acids into cyclopropanols. Distinct from conventional studies in Ti-mediated cyclopropanations with reactive alkyl Grignard reagents as nucleophiles or reductants, this protocol utilized Mg and Me2SiCl2 to turn over the Ti catalyst. This method exhibited broad substrate scope with good functional group compatibility and was amenable to late-stage synthetic manipulations of natural products and biol. active mols. In the experiment, the researchers used many compounds, for example, Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1Application of 5337-03-1).

Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Application of 5337-03-1

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Sorokin, Dimitry Y. et al. published their research in Systematic and Applied Microbiology in 2022 | CAS: 9004-53-9

Dextrin (cas: 9004-53-9) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineCategory: tetrahydropyran

Natronocalculus amylovorans gen. nov., sp. nov., and Natranaeroarchaeum aerophilus sp. nov., dominant culturable amylolytic natronoarchaea from hypersaline soda lakes in southwestern Siberia was written by Sorokin, Dimitry Y.;Elcheninov, Alexander G.;Khizhniak, Tatjana V.;Koenen, Michel;Bale, Nicole J.;Damste, Jaap S. Sinninghe;Kublanov, Ilya V.. And the article was included in Systematic and Applied Microbiology in 2022.Category: tetrahydropyran This article mentions the following:

Several pure cultures of alkaliphilic haloaloarchaea were enriched and isolated from hypersaline soda lakes in southwestern Siberia using amylopectin and fructans as substrates. Phylogenomic anal. placed the isolates into two distinct groups within the class Halobacteria. Four isolates forming group 1 were closely related to a recently described Natranaeroarchaeum sulfidigenes and the other three strains forming group 2 represent a novel genus-level phylogenetic lineage. All isolates are saccharolytic archaea growing with various starch-like alpha-glucans including soluble starch, amylopectin, dextrin, glycogen, pullulane and cyclodextrin. In addition, group 1 can use levan while group 2 – inulin (plant storage beta-fructans). Group 1 strains can also grow anaerobically with either glucose or maltose using elemental sulfur as the electron acceptor. Both groups are moderately alkaliphilic with a pH range for growth from 7.2 to 9.3 (optimum between 8.0-8.8) and low Mg-demanding extreme halophiles growing optimally at 4 M total Na+. The major respiratory menaquinone is MK-8:8 and the core biphytanyl lipids are dominated by archaeol (C20-C20) and a less abundant extended archaeol (C20-C25) with PG and PGP-Me as polar groups. The four isolates of group 1 are suggested to be classified into a new species as Natranaeroarchaeum aerophilus sp. nov. (type strain AArc-St1-1T = JCM 32519T = UQM 41458T). The three isolates of group 2 are proposed to form a new genus and species for which the name Natronocalculus amylovorans gen. nov., sp. nov. is suggested (type strain AArc-St2T = JCM 32475T = UQM 41459T). In the experiment, the researchers used many compounds, for example, Dextrin (cas: 9004-53-9Category: tetrahydropyran).

Dextrin (cas: 9004-53-9) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineCategory: tetrahydropyran

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Stortz, Carlos A. et al. published their research in Journal of Computational Chemistry in 2005 | CAS: 6581-66-4

2-Methoxytetrahydro-2H-pyran (cas: 6581-66-4) belongs to tetrahydropyran derivatives. In organic synthesis, the 2-tetrahydropyranyl group is used as a protecting group for alcohols. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineRecommanded Product: 2-Methoxytetrahydro-2H-pyran

Comparative performance of MM3(92) and two TINKER MM3 versions for the modeling of carbohydrates was written by Stortz, Carlos A.. And the article was included in Journal of Computational Chemistry in 2005.Recommanded Product: 2-Methoxytetrahydro-2H-pyran This article mentions the following:

The 1992 version of MM3 was largely used for modeling mono-, di-, and trisaccharides. In later versions of MM3 improvements were made in some parameters that may be important for carbohydrates. This corrected MM3 force field is part of the TINKER package, freely available (as its 4.1 version), and included in the Chem 3D Ultra 8.0 package (as the 3.7 version). The latter version lacks the corrections to the standard bond lengths produced by electronegativity and anomeric effects, whereas the TINKER 4.1 version only lacks the latter correction. The present work compares the performance of the three MM3 versions (and in some cases, DFT and/or HF/ab initio procedures) on several carbohydrate model problems as the chair and rotamer equilibrium in 2-hydroxy- and 2-methoxytetrahydropyran, hydrogen bonding in cis-2,3-dihydroxytetrahydropyran, and the potential energy surfaces around the glycosidic bonds of two sulfated disaccharides and two trisaccharides. TINKER MM3 can be used accurately to estimate carbohydrate energies and geometries, and-with the help of some programming-to pursue studies on the potential energy surfaces of di- and trisaccharides. In most cases results obtained using the three MM3 versions are similar, although large energy differences are obtained when comparing a rotameric distribution around a O-C-O-H dihedral, which is almost forced to the exo-anomeric position by the TINKER versions. In other systems smaller energy differences are found, but they can nevertheless lead to different global min. when comparing conformers of similar energy. MM3(92) establishes better the differences between the bond lengths in both anomers, as an expected expression of the anomeric correction. In the experiment, the researchers used many compounds, for example, 2-Methoxytetrahydro-2H-pyran (cas: 6581-66-4Recommanded Product: 2-Methoxytetrahydro-2H-pyran).

2-Methoxytetrahydro-2H-pyran (cas: 6581-66-4) belongs to tetrahydropyran derivatives. In organic synthesis, the 2-tetrahydropyranyl group is used as a protecting group for alcohols. There is large number of marine macrolide natural products that contain tetrahydropyran and tetrahydrofuran ring together. For instance, goniodomin A (actin targeting polyether), prorocentrolide (toxin halistatins), and percentotoxineRecommanded Product: 2-Methoxytetrahydro-2H-pyran

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Bhamare, V. G. et al. published their research in International Journal of Pharmaceutical Sciences and Research in 2021 | CAS: 41340-25-4

2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Product Details of 41340-25-4

Solubility enhancement of BCS class ii drugs was written by Bhamare, V. G.;Joshi, R. R.;Amrutkar, R. D.. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2021.Product Details of 41340-25-4 This article mentions the following:

One of the major barriers in the development of oral dosage form is poor solubility Poor water solubility obstructs drug bioavailability and decreases its pharmaceutical development. Many drugs are in the pipeline to enhance solubility to formulate dosage form to be taken by the most preferred route of administration that is the oral route. Etodolac is nonsteroidal anti-inflammatory drug having a wide spectrum of activities but belongs to BCS class II. The attempt has been made in this work to improve solubility by forming ternary inclusion complexes of Etodolac with PVP K30 and 尾-Cyclodextrins. The ternary inclusion complexes were prepared by the phys. mixing method and kneading method. The prepared complexes were analyzed by different anal. techniques comprising differential scanning calorimetry, IR spectroscopy and solubility study. Special emphasis was given on the solubility evaluation of drugs and complexes. Based on observations and results, one can easily conclude about the usefulness of the complexation technique for the enhancement of solubility In the experiment, the researchers used many compounds, for example, 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4Product Details of 41340-25-4).

2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Product Details of 41340-25-4

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics