Topical nanostructured lipid carrier (NLC) gel of etodolac: central composite design, optimization, in vitro skin penetration and dermatokinetic study was written by Patel, Dilip K.;Kesharwani, Roohi;Alhayyani, Sultan;Al-Abbasi, F. A.;Anwar, Firoz;Kumar, Vikas. And the article was included in Latin American Journal of Pharmacy in 2021.COA of Formula: C17H21NO3 This article mentions the following:
The objective of this investigation was to fabricate and evaluate a topical NLC based nanogel of etodolac. Topical nano formulation gel of drug was developed and its characterization variables were estimated The present work was optimized with the help of design expert software (central composite design). Etodolac encapsulated nanostructured lipid carrier were prepared by melt emulsification solidification at low temperature method (slight modification). Size distribution, efficiency of drug entrapment, ex vivo study, differential scanning calorimetry (DSC) of NLC dispersion. The optimized batch was evaluated for permeation data investigation, skin retention parameter by tape stripping technique and dermatokinetic study, pharmacodynamic studies of NLC gel encapsulated etodolac. The NLC formulations were developed in various size ranges from 224卤 to 613 nm. The etodolac entrapment efficacy and zeta potential of manufactured NLC were found to be 79.56 卤 1.04 to 86.04 卤 0.95% and -18.52 卤 0.58 to -22.80 卤 0.36 mV, resp. Dermatokinetic study in epidermis showed Cskin max 36.25 卤 2.64 cm2/h in case of NLC based nanogel while 18.25 卤 1.24 cm2/h in case of conventional gel suggesting that more penetration of etodolac from nano lipid based gel due to occlusive effect. In vivo study of etodolac nano gel is magnificent as compare to conventional gel that is able to decreases the edema beginning from 3rd hour and during time of study and offering sustaining anti-inflammatory action of etodolac NLC gel. In the experiment, the researchers used many compounds, for example, 2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4COA of Formula: C17H21NO3).
2-(1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid (cas: 41340-25-4) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. The bismuth chloride-assisted cross-cyclization between homoallylic alcohols and epoxides provided various benzyl tetrahydropyran derivatives. The reaction afforded good yields of desired products and occurred under mild conditions.COA of Formula: C17H21NO3
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics