Palladium-catalyzed dearomative 1,4-difunctionalization of naphthalenes was written by Yang, Ping;Zheng, Chao;Nie, Yu-Han;You, Shu-Li. And the article was included in Chemical Science in 2020.Application of 856414-68-1 This article mentions the following:
A highly diastereoselective dearomatization of naphthalenes via a Pd-catalyzed 1,4-difunctionalization reaction is described. In the presence of a com. available palladium precursor and ligand, intramol. dearomative Heck-type insertion provides 蟺-allylpalladium intermediates which are readily captured by a series of nucleophiles in excellent yields (up to 99%). This reaction features mild conditions, broad substrate scope, and useful transformations of the products. In the experiment, the researchers used many compounds, for example, Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate (cas: 856414-68-1Application of 856414-68-1).
Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate (cas: 856414-68-1) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Br酶nsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Application of 856414-68-1
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics