[3a,4]-Dihydropyrazolo[1,5a]pyrimidines: Novel, Potent, and Selective Phosphatidylinositol-3-kinase 尾 Inhibitors was written by Yu, Hongyi;Moore, Michael L.;Erhard, Karl;Hardwicke, Mary Ann;Lin, Hong;Luengo, Juan I.;McSurdy-Freed, Jeanelle;Plant, Ramona;Qu, Junya;Raha, Kaushik;Rominger, Cynthia M.;Schaber, Michael D.;Spengler, Michael D.;Rivero, Ralph A.. And the article was included in ACS Medicinal Chemistry Letters in 2013.Application In Synthesis of Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate This article mentions the following:
A series of novel [3a,4]dihydropyrazolo[1,5a]pyrimidines were identified, which were highly potent and selective inhibitors of PI3K尾 (e.g., I). The template afforded the opportunity to develop novel SAR for both the hinge-binding (morpholino) and back-pocket (OH) substituents. While cellular potency was relatively modest due to high protein binding, the series displayed low clearance in rat, mouse, and monkey. In the experiment, the researchers used many compounds, for example, Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate (cas: 856414-68-1Application In Synthesis of Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate).
Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate (cas: 856414-68-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Application In Synthesis of Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics