Synthesis of long-chain fatty acid derivatives as a novel anti-Alzheimer’s agent was written by Zhang, Hong-Yan;Yamakawa, Yu-ichiro;Matsuya, Yuji;Toyooka, Naoki;Tohda, Chihiro;Awale, Suresh;Li, Feng;Kadota, Shigetoshi;Tezuka, Yasuhiro. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Safety of 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran This article mentions the following:
In order to develop new drugs for Alzheimer’s disease, we prepared 17 fatty acid derivatives with different chain lengths and different numbers and positions of double bonds by using Wittig reaction and stereospecific hydrogenation of triple bonds as key reactions. Among them, (4Z,15Z)-octadecadienoic acid (10) and (23Z,34Z)-heptatriacontadienoic acid (16) showed the most potent neurite outgrowth activities on A尾(25-35)-treated rat cortical neurons, which activities were comparable to that of a pos. control, NGF. Both fatty acids 10 and 16 possess two (Z)-double bonds at the n-3 and n-14 positions, which might be important for the neurite outgrowth activity. In the experiment, the researchers used many compounds, for example, 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5Safety of 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran).
2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Br酶nsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Safety of 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics