Identification of Gentiana rigescens from different geographical origins based on HPLC and FTIR fingerprints was written by Zhao, Yanli;Yuan, Tianjun;Wu, Lihua;Zhang, Ji;Zuo, Zhitian;Wang, Yuanzhong. And the article was included in Analytical Methods in 2020.Related Products of 17388-39-5 This article mentions the following:
Gentiana rigescens is a traditional Chinese medicine with efficacy in liver protection, as a cholagogic, anti-hyperglycemic, and anti-hypertension agent, and in relieving spasms and pain. The geog. environments of different locations are very complicated, with different soils, climates, sun exposure, etc.; this has a remarkable effect on the quality of medicinal herbs. To identify different geog. origins of G. rigescens, we analyzed the high-performance liquid chromatog. (HPLC) and Fourier transform IR spectroscopy (FTIR) fingerprints of G. rigescens with the aid of chemometrics. Five variable selection methods, including competitive adaptive reweighted sampling (CARS), random frog (RF), subwindow permutation anal. (SPA), Monte Carlo uninformative variable elimination (MC-UVE) and genetic algorithms (GA), were used to screen the characteristic variables for both the HPLC and FTIR fingerprints. Then, the corresponding partial least squares discriminant anal. (PLS-DA) models were built. The results showed that for both HPLC and FTIR, the GA-PLS-DA models were the most robust models for identification of the geog. origins of G. rigescens, which indicated that the recognition results of HPLC and FTIR are consistent. Through HPLC-FTIR two-dimensional (2D) hetero-correlation anal., the results showed a substantial correlation between HPLC and FTIR, which suggests that spectral correlative chromatog. for multicomponent comparison can be conducted. In terms of G. rigescens, qual. identification using FTIR is more convenient, rapid, environment-friendly and inexpensive than that using HPLC. In the experiment, the researchers used many compounds, for example, (4aR,5R,6S)-4a-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-4,4a,5,6-tetrahydropyrano[3,4-c]pyran-1(3H)-one (cas: 17388-39-5Related Products of 17388-39-5).
(4aR,5R,6S)-4a-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-4,4a,5,6-tetrahydropyrano[3,4-c]pyran-1(3H)-one (cas: 17388-39-5) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. Related Products of 17388-39-5
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics