Formulation, phytochemical estimation of active principles by spectroscopic methods and comparison of the poly herbal anti-diabetic tablet with the commercial tablets was written by Chauhan, Nidhi N.;Mistry, Rujuta;Vasava, Parul;Mandale, Drasti. And the article was included in International Journal of Pharmaceutical Sciences and Drug Research in 2021.Category: tetrahydropyran This article mentions the following:
Diabetes mellitus is a group of metabolic disorders characterized by increased glucose levels over a prolonged period. The poly-herbal anti-diabetic tablet was formulated in the laboratory by using herbs of Enicostemma littorale (EL) (Gentianaceae), roots of Aconitum heterophyllum (AH) (Ranunculaceae), rhizomes of Picrorhiza kurroa (PK) (Scrophulariaceae), and fruits of Piper longum (PL) (Piperaceae). Furthermore, Laboratory formulation (LF) and Marketed formulations (MFs) were tested for Phytochem. screening and Qual. chem. examination From their result, isolation of active principles, Swertiamarin (EL-1) and Piperine (PN-1), was done and subjected to phytochem. examination by Modern anal. methods like TLC, UV, FTIR. Finally, the quantification and estimation of the afore-mentioned compounds were achieved by HPTLC. SSE of all the four formulations and the chem. tests proved alkaloids, flavonoids, carbohydrates, tannins, phenols and phytosterols. Comparing the data from the m.p., TLC, UV, and IR studies of EL-1 and PN-1 with standard Biomarkers, further calculation of both markers concentrations was done with the help of the calibration equation and the peak area derived from the chromatogram. Study outcomes signify that LF was more potent than MFs for anti-diabetic activity, signifying as a promising natural and safe remedy for the prevention of diabetic complications. In the experiment, the researchers used many compounds, for example, (4aR,5R,6S)-4a-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-4,4a,5,6-tetrahydropyrano[3,4-c]pyran-1(3H)-one (cas: 17388-39-5Category: tetrahydropyran).
(4aR,5R,6S)-4a-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-4,4a,5,6-tetrahydropyrano[3,4-c]pyran-1(3H)-one (cas: 17388-39-5) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. The bismuth chloride-assisted cross-cyclization between homoallylic alcohols and epoxides provided various benzyl tetrahydropyran derivatives. The reaction afforded good yields of desired products and occurred under mild conditions.Category: tetrahydropyran
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics