Organophotoredox-catalyzed semipinacol rearrangement via radical-polar crossover was written by Kodo, Taiga;Nagao, Kazunori;Ohmiya, Hirohisa. And the article was included in Nature Communications in 2022.COA of Formula: C6H10O3 This article mentions the following:
The organophotoredox-catalyzed semipinacol rearrangement via radical-polar crossover (RPC) was reported. A phenothiazine-based organophotoredox catalyst facilitates the generation of an α-hydroxy non-benzylic alkyl radical followed by oxidation to the corresponding carbocation, which was exploited to undergo the semipinacol rearrangement. As a result, the photochem. approach enables decarboxylative semipinacol rearrangement of β-hydroxycarboxylic acid derivatives and alkylative semipinacol type rearrangement of allyl alcs. with carbon electrophiles, producing α-quaternary or α-tertiary carbonyls bearing sp3-rich scaffolds. In the experiment, the researchers used many compounds, for example, Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1COA of Formula: C6H10O3).
Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.COA of Formula: C6H10O3
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics