The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex-Part 2 was written by Kohrt, Jeffrey T.;Filipski, Kevin J.;Cody, Wayne L.;Cai, Cuiman;Dudley, Danette A.;Van Huis, Chad A.;Willardsen, J. Adam;Narasimhan, Lakshmi S.;Zhang, Erli;Rapundalo, Stephen T.;Saiya-Cork, Kamlai;Leadley, Robert J.;Edmunds, Jeremy J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Recommanded Product: 2-(Aminomethyl)tetrahydropyran This article mentions the following:
The activated factor VII/tissue factor complex (FVIIa/TF) is known to play a key role in the formation of blood clots. Inhibition of this complex may lead to new antithrombotic drugs. A fluoropyridine-based series of FVIIa/TF inhibitors was discovered which utilized a diisopropylamino group for binding in the S2 and S3 binding pockets of the active site of the enzyme complex. In this series, an enhancement in binding affinity was observed by substitution at the 5-position of the hydroxybenzoic acid sidechain. An X-ray crystal structure indicates that amides at this position may increase inhibitor binding affinity through interactions with the S1’/S2′ pocket. In the experiment, the researchers used many compounds, for example, 2-(Aminomethyl)tetrahydropyran (cas: 6628-83-7Recommanded Product: 2-(Aminomethyl)tetrahydropyran).
2-(Aminomethyl)tetrahydropyran (cas: 6628-83-7) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. The bismuth chloride-assisted cross-cyclization between homoallylic alcohols and epoxides provided various benzyl tetrahydropyran derivatives. The reaction afforded good yields of desired products and occurred under mild conditions.Recommanded Product: 2-(Aminomethyl)tetrahydropyran
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics