2-Aminopyrimidin-4(1H)-one as the novel bioisostere of urea: Discovery of novel and potent CXCR2 antagonists was written by Lu, Hongfu;Yang, Ting;Xu, Zhongmiao;Wren, Paul B.;Zhang, Yueting;Cai, Xin;Patel, Metul;Dong, Kelly;Zhang, Qing;Zhang, Wei;Guan, Xiaoming;Xiang, Jianing;Elliott, John D.;Lin, Xichen;Ren, Feng. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Category: tetrahydropyran This article mentions the following:
2-Aminopyrimidin-4(1H)-one was proposed as the novel bioisostere of urea. Bioisosteric replacement of the reported urea series of the CXCR2 antagonists with 2-aminopyrimidin-4(1H)-ones led to the discovery of the novel and potent CXCR2 antagonist I. 2-Aminopyrimidin-4(1H)-one I demonstrated a good potential (reasonable solubility and high permeability) and superior chem. stability especially in simulated gastric fluid compared with ureas. In the experiment, the researchers used many compounds, for example, Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate (cas: 856414-68-1Category: tetrahydropyran).
Ethyl 3-Oxo-3-(4-tetrahydropyranyl)propanoate (cas: 856414-68-1) belongs to tetrahydropyran derivatives. Dihydropyrans and tetrahydropyrans are examples of cyclic ethers widespread in nature. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. Category: tetrahydropyran
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics