Wang, Qile et al. published their research in Organic Letters in 2019 | CAS: 40365-61-5

2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.HPLC of Formula: 40365-61-5

A Photocatalyzed Cascade Approach Toward the Tetracyclic Core of Akuammiline Alkaloids was written by Wang, Qile;Hu, Jie;Zheng, Nan. And the article was included in Organic Letters in 2019.HPLC of Formula: 40365-61-5 This article mentions the following:

A cascade approach toward the tetracyclic core (e.g. I) of akuammiline alkaloids which features high modularity and convergence is reported. Distinct substitution pattern can be readily introduced to the tetracyclic core by varying three building blocks with similar complexity. The critical event in the cascade is a regio- and stereoselective 1,2-shift enabled by a carbocation that sets up the core. In the experiment, the researchers used many compounds, for example, 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5HPLC of Formula: 40365-61-5).

2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.HPLC of Formula: 40365-61-5

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Alamholo, Mostafa et al. published their research in Pharmaceutical and Biomedical Research in 2021 | CAS: 6581-66-4

2-Methoxytetrahydro-2H-pyran (cas: 6581-66-4) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.SDS of cas: 6581-66-4

Evaluation of susceptibility and resistance of human infectious bacteria and identification of bioactive compounds in Pistacia atlantica, Cassia absus, and Quercus persica was written by Alamholo, Mostafa;Amraie, Yosof. And the article was included in Pharmaceutical and Biomedical Research in 2021.SDS of cas: 6581-66-4 This article mentions the following:

Background: The antimicrobial activity of plants has long been considered an effective mechanism for controlling pathogenic microorganisms. Objectives: This study aimed to identify phytochem. compounds of the seed extracts from ethnomedicinal plants of Pistacia atlantica, Cassia absus, and Quercus persica with Gas Chromatog.-Mass Spectrometry (GC-MS) and investigation of their antibacterial and antioxidant activities. Methods: The seeds were collected from Lorestan Province, Iran. Their antibacterial and antiradical activities were analyzed by disk-diffusion and 2,2-diphenyl-1-picrylhydrazyl assays, resp. Ethanol (96%), methanol (80%), and distilled water extracts were obtained by the maceration method. The methanol extract was used for the anal. of chem. compositions Results: About 40, 31, and 8 compounds were identified by GC-MS in the seeds of Cassia absus, Pistacia atlantica, and Quercus persica, resp. Results indicated that 2,4-di-tertbutylphenol (36.043%) and tetradecanoic acid (4.92%) were dominated in the seed extracts of Cassia absus. However, germacyclopetene (38.119%) and 1,2,3-benzenetriol (8.115%) were dominated in the seed extracts of Pistacia atlantica. Furthermore, 5H-tetrazole-5-thione, 1,4-dihydro-1,4-dimethy (38.505%), and tetradecanoic acid (30.546%) were dominated in the seed extracts of Quercus persica. The strongest radical scavenging activity and the highest inhibitory activity against M. luteus were observed on the methanol extract of C. absus. was changed to The highest inhibitory activity against M. luteus was observed on the methanol extract of C. absus. Conclusion: Because of the presence of antimicrobial compounds in the tested ethnomedicinal plants, they can be used to synthesize new antimicrobial drugs in medicinal and pharmaceutical sciences. In the experiment, the researchers used many compounds, for example, 2-Methoxytetrahydro-2H-pyran (cas: 6581-66-4SDS of cas: 6581-66-4).

2-Methoxytetrahydro-2H-pyran (cas: 6581-66-4) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.SDS of cas: 6581-66-4

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Sivakumaran, G. et al. published their research in International Journal of Pharmaceutical Sciences Review and Research in 2016 | CAS: 40365-61-5

2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Recommanded Product: 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran

Preliminary GC-MS anlaysis and antioxidant study of one ayurvedic medicine “Manasa mitra vatakam” was written by Sivakumaran, G.;Rao, Mudiganti Ram Krishna;Prabhu, K.;Kalaiselvi, V. S.;Jones, Sumathi;Johnson, W. M.;Antony, J.. And the article was included in International Journal of Pharmaceutical Sciences Review and Research in 2016.Recommanded Product: 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran This article mentions the following:

The authenticity of the medicinal efficacy of Ayurvedic and Siddha medicines is of great importance in the present day surge in the use of complimentary and alternative medicines. The present study is a step in this direction. Manasamitra vatakam is an Ayurvedic medicine used for the treatment of mental disorders, anxiety etc. This medicince is made of many components which are of plant, animal and mineral origin. The GC MS anal. revealed the presence of some important biomolecuels like 13-Docosenamide,(Z)-, n- Hexadecanoic acid, Oleic Acid, Borneol, Octadecanoic acid, 9-Octadecenoic acid, (E)-, Isoamyl cinnamate, 1-Heptadecanamine Disilane, 9-Octadecenamide, (Z)-, (diphenylmethyl)pentaphenyl-, Undecanoic acid, 11-amino-, Erucic acid, Tetradecanamide, Squalene among other minor components. These biomols. have reflections on the role of this medicine. The antioxidant study also indicated that this medicine has strong properties as antioxidant. Further study however is warranted to prove the medicinal efficacy of this medicine. In the experiment, the researchers used many compounds, for example, 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5Recommanded Product: 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran).

2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Recommanded Product: 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Vinelli, Valentina et al. published their research in Nutrients in 2022 | CAS: 9004-53-9

Dextrin (cas: 9004-53-9) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. Computed Properties of 0

Effects of Dietary Fibers on Short-Chain Fatty Acids and Gut Microbiota Composition in Healthy Adults: A Systematic Review was written by Vinelli, Valentina;Biscotti, Paola;Martini, Daniela;Del Bo’, Cristian;Marino, Mirko;Merono, Tomas;Nikoloudaki, Olga;Calabrese, Francesco Maria;Turroni, Silvia;Taverniti, Valentina;Union Caballero, Andrea;Andres-Lacueva, Cristina;Porrini, Marisa;Gobbetti, Marco;De Angelis, Maria;Brigidi, Patrizia;Pinart, Mariona;Nimptsch, Katharina;Guglielmetti, Simone;Riso, Patrizia. And the article was included in Nutrients in 2022.Computed Properties of 0 This article mentions the following:

There is an increasing interest in investigating dietary strategies able to modulate the gut microbial ecosystem which, in turn, may play a key role in human health. Dietary fibers (DFs) are widely recognized as mols. with prebiotic effects. The main objective of this systematic review was to: (i) analyze the results available on the impact of DF intervention on short chain fatty acids (SCFAs) production; (ii) evaluate the interplay between the type of DF intervention, the gut microbiota composition and its metabolic activities, and any other health associated outcome evaluated in the host. To this aim, initially, a comprehensive database of literature on human intervention studies assessing the effect of confirmed and candidate prebiotics on the microbial ecosystem was developed. Subsequently, studies performed on DFs and analyzing at least the impact on SCFA levels were extracted from the database. A total of 44 studies from 42 manuscripts were selected for the anal. Among the different types of fiber, inulin was the DF investigated the most (n = 11). Regarding the results obtained on the ability of fiber to modulate total SCFAs, seven studies reported a significant increase, while no significant changes were reported in five studies, depending on the anal. methodol. used. A total of 26 studies did not show significant differences in individual SCFAs, while the others reported significant differences for one or more SCFAs. The effect of DF interventions on the SCFA profile seemed to be strictly dependent on the dose and the type and structure of DFs. Overall, these results underline that, although affecting microbiota composition and derived metabolites, DFs do not produce univocal significant increase in SCFA levels in apparently healthy adults. In this regard, several factors (i.e., related to the study protocols and anal. methods) have been identified that could have affected the results obtained in the studies evaluated. Future studies are needed to better elucidate the relationship between DFs and gut microbiota in terms of SCFA production and impact on health-related markers. In the experiment, the researchers used many compounds, for example, Dextrin (cas: 9004-53-9Computed Properties of 0).

Dextrin (cas: 9004-53-9) belongs to tetrahydropyran derivatives. Numerous natural products have tetrahydropyran skeleton as the building block for designing new natural products and their derivatives e.g. aplysiatoxins, avermectins, oscillatoxins, talaromycins, latrunculins and acutiphycins. The most notable anticancer agent, bryostatin, and eribulin are marine macrolides having intriguing tetrahydropyran and furan motif. Computed Properties of 0

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Bouchery, Tiffany et al. published their research in Immunology & Cell Biology in 2022 | CAS: 9008-22-4

Laminarin (cas: 9008-22-4) belongs to tetrahydropyran derivatives. In organic synthesis, the 2-tetrahydropyranyl group is used as a protecting group for alcohols. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Related Products of 9008-22-4

β-Glucan receptors on IL-4 activated macrophages are required for hookworm larvae recognition and trapping was written by Bouchery, Tiffany;Volpe, Beatrice;Doolan, Rory;Coakley, Gillian;Moyat, Mati;Esser-von Bieren, Julia;Wickramasinghe, Lakshanie C.;Hibbs, Margaret L.;Sotillo, Javier;Camberis, Mali;Le Gros, Graham;Khan, Nemat;Williams, David;Harris, Nicola L.. And the article was included in Immunology & Cell Biology in 2022.Related Products of 9008-22-4 This article mentions the following:

Recent advances in the field of host immunity against parasitic nematodes have revealed the importance of macrophages in trapping tissue migratory larvae. Protective immune mechanisms against the rodent hookworm Nippostrongylus brasiliensis (Nb) are mediated, at least in part, by IL-4-activated macrophages that bind and trap larvae in the lung. However, it is still not clear how host macrophages recognize the parasite. An in vitro co-culture system of bone marrow-derived macrophages and Nb infective larvae was utilized to screen for the possible ligand-receptor pair involved in macrophage attack of larvae. Competitive binding assays revealed an important role for β-glucan recognition in the process. We further identified a role for CD11b and the non-classical pattern recognition receptor ephrin-A2 (EphA2), but not the highly expressed β-glucan dectin-1 receptor, in this process of recognition. This work raises the possibility that parasitic nematodes synthesize β-glucans and it identifies CD11b and ephrin-A2 as important pattern recognition receptors involved in the host recognition of these evolutionary old pathogens. To our knowledge, this is the first time that EphA2 has been implicated in immune responses to a helminth. In the experiment, the researchers used many compounds, for example, Laminarin (cas: 9008-22-4Related Products of 9008-22-4).

Laminarin (cas: 9008-22-4) belongs to tetrahydropyran derivatives. In organic synthesis, the 2-tetrahydropyranyl group is used as a protecting group for alcohols. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Related Products of 9008-22-4

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Abdelhalim, Abdelsattar O. E. et al. published their research in Journal of Molecular Liquids in 2022 | CAS: 11024-24-1

Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Electric Literature of C56H92O29

Graphene oxide conjugated with doxorubicin: Synthesis, bioactivity, and biosafety was written by Abdelhalim, Abdelsattar O. E.;Ageev, Sergei V.;Petrov, Andrey V.;Meshcheriakov, Anatolii A.;Luttsev, Mikhail D.;Vasina, Lubov V.;Nashchekina, Iuliia A.;Murin, Igor V.;Molchanov, Oleg E.;Maistrenko, Dmitrii N.;Potanin, Artem A.;Semenov, Konstantin N.;Sharoyko, Vladimir V.. And the article was included in Journal of Molecular Liquids in 2022.Electric Literature of C56H92O29 This article mentions the following:

This work presents a method for covalent functionalization of GO with a cytostatic preparation DOX with a loading of 87%. The resulting nanomaterial was characterized using modern physicochem. methods (13C NMR, Raman, IR, UV/Vis spectroscopy, XPS, XRD, HRTEM). The synthesized conjugate showed significant antiaggregating activity and selective cytotoxicity towards the A549 cell line, significantly superior to individual DOX, as well as low cytotoxicity towards the non-cancer cell line HEK293. The complex biocompatibility study was conducted for the synthesized conjugate including hemocompatibility study, antioxidant activity, interaction with HSA and DNA, geno- and cytotoxicity investigation. At the same time, mol. dynamics investigation was performed in order to determine the features of intermol. interaction between GO and DOX mols. In the experiment, the researchers used many compounds, for example, Digitonin (cas: 11024-24-1Electric Literature of C56H92O29).

Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans are also used as important solvents, as chemical intermediate and as monomer for ring-opening polymerization. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.Electric Literature of C56H92O29

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Jin, Shengnan et al. published their research in Journal of the American Chemical Society in 2021 | CAS: 40365-61-5

2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Application In Synthesis of 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran

Enantioselective Cobalt-Catalyzed Cascade Hydrosilylation and Hydroboration of Alkynes to Access Enantioenriched 1,1-Silylboryl Alkanes was written by Jin, Shengnan;Liu, Kang;Wang, Shuai;Song, Qiuling. And the article was included in Journal of the American Chemical Society in 2021.Application In Synthesis of 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran This article mentions the following:

Enantioenriched 1,1-silylboryl alkanes possess silyl and boryl groups that are both connected to the same stereogenic carbon center at well-defined orientations. As these chiral multifunctionalized compounds potentially offer two synthetic handles, they are highly valued building blocks in asym. synthesis as well as medicinal chem. Despite the potential usefulness, efficient synthetic approaches for their preparation are scarce. Seeking to address this deficiency, an enantioselective cobalt-catalyzed hydrosilylation/hydroboration cascade of terminal alkynes has been realized. This protocol constitutes an impressive case of chemo-, regio-, and stereoselectivity wherein the two different hydrofunctionalization events are exquisitely controlled by a single set of metal catalyst and ligand, an operation which would usually require two sep. catalytic systems. Downstream transformations of enantioenriched 1,1-silyboryl alkanes led to various valuable chiral compounds Mechanistic studies suggest that the present reaction undergoes highly regioselective and stereocontrolled sequential hydrosilylation and hydroboration processes. In the experiment, the researchers used many compounds, for example, 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5Application In Synthesis of 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran).

2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Application In Synthesis of 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Chen, Yi et al. published their research in Huaxi Yaoxue Zazhi in 2012 | CAS: 40365-61-5

2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Recommanded Product: 40365-61-5

Synthesis of the precursor compound of anti-tumor natural product ainsliatrimer A was written by Chen, Yi;Song, Hao. And the article was included in Huaxi Yaoxue Zazhi in 2012.Recommanded Product: 40365-61-5 This article mentions the following:

The precursor compound of anti-tumor natural product ainsliatrimer A was synthesized. The target precursor compound of anti-tumor natural product ainsliatrimer A was obtained by nucleophilic substitution, Wittig reaction, carbonyl radical addition and other key reactions with starting material of tert-Bu (5-iodopentyloxy) dimethylsilane. The target precursor compound of ainsliatrimer A was successfully synthesized, which laid the foundation for the total synthesis of compounds ainsliatrimer A and ainsliatrimer B, through a 7-step reaction with overall yield of 27.1%. In the experiment, the researchers used many compounds, for example, 2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5Recommanded Product: 40365-61-5).

2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran (cas: 40365-61-5) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. 2-(Arylmethylene)cyclopropylcarbinols could be converted to the corresponding tetrahydropyrans stereoselectively in the presence of Brønsted acids under mild conditions. A plausible Prins-type reaction mechanism has been proposed.Recommanded Product: 40365-61-5

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Chen, Lanchai et al. published their research in Microbial Cell Factories in 2021 | CAS: 9008-22-4

Laminarin (cas: 9008-22-4) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.HPLC of Formula: 9008-22-4

Biochemical and synergistic properties of a novel alpha-amylase from Chinese nong-flavor Daqu was written by Chen, Lanchai;Yi, Zhuolin;Fang, Yang;Jin, Yanling;He, Kaize;Xiao, Yao;Zhao, Dong;Luo, Huibo;He, Hui;Sun, Qun;Zhao, Hai. And the article was included in Microbial Cell Factories in 2021.HPLC of Formula: 9008-22-4 This article mentions the following:

Daqu is the most important fermentation starter for Chinese liquor, with large number of microbes and enzymes being openly enriched in the Daqu system over thousands of years. However, only a few enzymes have been analyzed with crude protein for total liquefying power and saccharifying power of Daqu. Therefore, the complex enzymic system present in Daqu has not been completely characterized. Moreover, their pivotal and complicated functions in Daqu are completely unknown. In this study, a novel α-amylase NFAmy13B, from GH13_5 subfamily (according to the Carbohydrate-Active enZYmes Database, CAZy) was successfully heterologous expressed by Escherichia coli from Chinese Nong-flavor (NF) Daqu. It exhibited high stability ranging from pH 5.5 to 12.5, and higher specific activity, compared to other GH13_5 fungal α-amylases. Moreover, NFAmy13B did not show activity loss and retained 96% residual activity after pre-incubation at pH 11 for 21 h and pH 12 for 10 h, resp. Addnl., 1.25 mM Ca2+ significantly improved its thermostability. NFAmy13B showed a synergistic effect on degrading wheat starch with NFAmy13A (GH13_1), another α-amylase from Daqu. Both enzymes could cleave maltotetraose and maltopentaose in same degradation pattern, and only NFAmy13A could efficiently degrade maltotriose. Moreover, NFAmy13B showed higher catalytic efficiency on long-chain starch, while NFAmy13A had higher catalytic efficiency on short-chain maltooligosaccharides. Their different catalytic efficiencies on starch and maltooligosaccharides may be caused by their discrepant substrate-binding region. This study mined a novel GH13_5 fungal α-amylase (NFAmy13B) with outstanding alkali resistance from Nong-flavor (NF) Daqu. Furthermore, its synergistic effect with NFAmy13A (GH13_1) on hydrolyzing wheat starch was confirmed, and their possible contribution in NF Daqu was also speculated. Thus, we not only provide a candidate α-amylase for industry, but also a useful strategy for further studying the interactions in the complex enzyme system of Daqu. The nucleotide sequence of NFAmy13B obtained from the N3 cDNA library was deposited in the NCBI GenBank database under Accession Number MT849765. In the experiment, the researchers used many compounds, for example, Laminarin (cas: 9008-22-4HPLC of Formula: 9008-22-4).

Laminarin (cas: 9008-22-4) belongs to tetrahydropyran derivatives. Tetrahydropyrans are useful synthons for biologically important compounds. The reaction of tertiary 1,4- and 1,5-diols with cerium ammonium nitrate at room temperature gives tetrahydrofuran and tetrahydropyran derivatives in high yield and stereoselectivity. Various fragrant compounds have been synthesized using this method.HPLC of Formula: 9008-22-4

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Oostdyk, Luke T. et al. published their research in Scientific Reports in 2020 | CAS: 11024-24-1

Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. The Prins reaction of homoallylic alcohols with aldehydes afforded an alternative method for the preparation of tetrahydropyrans.Reference of 11024-24-1

An epilepsy-associated mutation in the nuclear import receptor KPNA7 reduces nuclear localization signal binding was written by Oostdyk, Luke T.;Wang, Zhenjia;Zang, Chongzhi;Li, Hui;McConnell, Michael J.;Paschal, Bryce M.. And the article was included in Scientific Reports in 2020.Reference of 11024-24-1 This article mentions the following:

KPNA7 is a member of the Importin-a family of nuclear import receptors. KPNA7 forms a complex with Importin-β and facilitates the translocation of signal-containing proteins from the cytoplasm to the nucleus. Exome sequencing of siblings with severe neurodevelopmental deffects and clin. features of epilepsy identified two amino acid-altering mutations in KPNA7. Here, we show that the E344Q substitution reduces KPNA7 binding to nuclear localization signals, and that this limits KPNA7 nuclear import activity. The P339A substitution, by contrast, has little effect on KPNA7 binding to nuclear localization signals. Given the neuronal phenotype described in the two patients, we used SILAC labeling, affinity enrichment, and mass spectrometry to identify KPNA7-interacting proteins in human induced pluripotent stem cell-derived neurons. We identified heterogeneous nuclear ribonucleoproteins hnRNP R and hnRNP U as KPNA7-interacting proteins. The E344Q substitution reduced binding and KPNA7-mediated import of these cargoes. The c.1030G > C allele which generates E344Q is within a predicted CTCF binding site, and we found that it reduces CTCF binding by approx. 40-fold. Our data support a role for altered neuronal expression and activity of KPNA7 in a rare type of pediatric epilepsy. In the experiment, the researchers used many compounds, for example, Digitonin (cas: 11024-24-1Reference of 11024-24-1).

Digitonin (cas: 11024-24-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. The Prins reaction of homoallylic alcohols with aldehydes afforded an alternative method for the preparation of tetrahydropyrans.Reference of 11024-24-1

Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics