A facile method for Rh-catalyzed decarbonylative ortho-C-H alkylation of (hetero)arenes with alkyl carboxylic acids was written by Tian, Yiqiang;Liu, Xiaojie;He, Bangyue;Ren, Yuxi;Su, Weiping. And the article was included in RSC Advances in 2021.Formula: C6H10O3 This article mentions the following:
A facile and effective method for Rh-catalyzed direct ortho-alkylation of C-H bonds in (hetero)arenes I (R = 2-methylphenyl, naphthalen-1-yl, thiophen-2-yl, etc.) with com. available carboxylic acids R1COOH (R1 = Et, cyclopentyl, 2-(4-bromophenyl)ethyl, etc.) has been developed. This strategy was initiated by in situ conversion of carboxylic acids to anhydrides which, without isolation, underwent Rh-catalyzed direct decarbonylative cross-coupling of aryl carboxamides containing 8-aminoquinoline I (R = 2,6-diethylphenyl, 2-cyclopentyl-6-methylphenyl, 2-methyl-6-phenylphenyl, etc.). The reaction proceeds with high regioselectivity and exhibits a broad substrate scope as well as functional group tolerance. In the experiment, the researchers used many compounds, for example, Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1Formula: C6H10O3).
Tetrahydropyran-4-yl-carboxylic acid (cas: 5337-03-1) belongs to tetrahydropyran derivatives. Tetrahydropyrans and furans principally constitute as a central motif in diverse medicinally privileged molecules. The Prins reaction of homoallylic alcohols with aldehydes afforded an alternative method for the preparation of tetrahydropyrans.Formula: C6H10O3
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics