Ferrous methanesulfonate as an efficient and recyclable catalyst for the tetrahydropyranylation of alcohols and phenols under solvent-free conditions was written by Wang, Min;Song, Zhiguo;Wan, Xin;Zhao, Shuang. And the article was included in RSC Advances in 2011.Application of 6581-66-4 This article mentions the following:
The synthesis of the target compounds was achieved by a ferrous methanesulfonate-catalyzed tetrahydropyranylation of alcs. (benzylic, primary, isomeric alcs., tertiary, cyclic, allyl and furyl) and phenols at room temperature under solvent-free conditions (green chem. method). The catalytic activity of sixteen metal methanesulfonates was compared under the same conditions, ferrous methanesulfonate proved to be the best. It can be recovered easily and reused for several times without distinct deterioration in catalytic activity. During a competitive protection of the hydroxyl groups between an alc. and a phenol, tetrahydropyranyl ether formed exclusively with the alc. A possible catalytic mechanism was proposed. In the experiment, the researchers used many compounds, for example, 2-Methoxytetrahydro-2H-pyran (cas: 6581-66-4Application of 6581-66-4).
2-Methoxytetrahydro-2H-pyran (cas: 6581-66-4) belongs to tetrahydropyran derivatives. Tetrahydropyran is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and dyestuff. One classic procedure for the organic synthesis of tetrahydropyran is by hydrogenation of the 3,4-isomer of dihydropyran with Raney nickel.Application of 6581-66-4
Referemce:
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics