In an article, published in an article, once mentioned the application of 499-40-1, Name is (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal,molecular formula is C12H22O11, is a conventional compound. this article was the specific content is as follows.category: Tetrahydropyrans
Nickel-diflunisal complexes: Synthesis, characterization, in vitro antioxidant activity and interaction with DNA and albumins
The reaction of NiCl2 with the non-steroidal anti-inflammatory drug diflunisal (Hdifl) resulted in the formation of complex [Ni(difl-O)2(MeOH)4], 1. The co-existence of a N,N’-donor heterocyclic ligand 2,2?-dipyridylketone oxime (Hpko), 1,10-phenanthroline (phen), 2,2?-bipyridine (bipy) and 2,2?-bipyridylamine (bipyam) led to the formation of complexes [Ni(difl-O)2(Hpko-N,N’)2], 2, [Ni(difl)2(phen)(MeOH)2], 3, [Ni(difl)2(bipy)(MeOH)2], 4 and [Ni(difl-O,O’)2(bipyam)], 5, respectively. The complexes were characterized by physicochemical and spectroscopic techniques and the crystal structures of complexes 1 and 2 were determined by X-ray crystallography. The ability of the complexes to scavenge in vitro 1,1-diphenyl-picrylhydrazyl, 2,2?-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) and hydroxyl radicals was investigated; the complexes were more active scavengers than free Hdifl. The interaction of the complexes with serum albumins was investigated by fluorescence emission spectroscopy and the binding constants of the compounds to the albumins were calculated. UV spectroscopy, cyclic voltammetry and viscosity measurements as well as fluorescence emission spectroscopy for the competitive studies of the complexes with ethidium bromide were employed so as to monitor the interaction of the compounds with calf-thymus DNA and revealed intercalation as the most possible mode of binding.
Do you like my blog? If you like, you can also browse other articles about this kind. category: Tetrahydropyrans. Thanks for taking the time to read the blog about 499-40-1
Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics