85064-61-5, Tetrahydropyranyl-4-acetic acid is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,85064-61-5
At room temperature, to the containing (3-(3-amino-5-chloro-2-methylbenzyl)-3,8-diazabicyclo[3.2.1]octan-8-yl) tetrahydro-2H-pyran-4-yl methanone (45.0 mg, 0 . 12 mmol) in dichloromethane solution, adding N, N – diisopropyl ethylamine (46.4 mg, 0 . 36 mmol) and tetrahydropyran-4-acetic acid (18.7 mg, 0 . 13 mmol), addition of HATU (114.0 mg, 0.3 mmol), after the adding of, for stirring at room temperature overnight the reaction. After the reaction is complete, the solvent is removed under reduced pressure, the residue by silica gel column chromatography (petroleum ether: ethyl acetate=5:1 – 1:1) and thick preparation plate to obtain the colorless solid compound 20.0 mg, yield 33.1percent.
The synthetic route of 85064-61-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Fudan University; Wang Yonghui; Tian Jinlong; Yu Mingcheng; (29 pag.)CN109134476; (2019); A;,
Tetrahydropyran – Wikipedia
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