624734-17-4, 3-Methoxydihydro-2H-pyran-4(3H)-one is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,624734-17-4
A mixture of the product from Step B (99.8 mg, 0.156 mmol), 3-methoxydihydro-2H-pyran-4(JH)-one (60.91 mg, 0.468 mmol), 4A molecular sieves (0.2 g) and TEA (0.065 lmL, 0.468 mmol) in DCM (2 mL) was stirred at rt for 2 h, followed by addition of sodium triacetoxyborohydride (66.13 mg, 0.312 mmol). The resulting mixture was stirred at rt overnight. The reaction was quenched by addition of saturated NaHC03 aqueous solution, extracted with DCM, and dried over Na2S04. After removal of the solvent, the residue was purified by column chromatography (eluent: 5% 7N NH3 in methanol in DCM) to give the product as a yellowish gel. 1H-NMR (400 MHz, CDC13): delta 1.52 – 1.95 (m, 4H), 2.34 (br. s., 1 H), 2.61 – 2.89 (m, 6 H), 3.03 – 3.61 (m, 11 H), 3.63 – 4.13 (m, 7 H), 4.27 (br. s., 1 H), 4.57 – 5.11 (m, 2 H), 7.69 (br. s., 1 H), 8.71 (br. s., 1 H); LC/MS: C25H34F3N504: m/z 526.2 (M+H).
The synthetic route of 624734-17-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; CAI, Chaozhong; MCCOMSEY, David F.; SUI, Zhihua; KANG, Fu An; WO2014/14901; (2014); A1;,
Tetrahydropyran – Wikipedia
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