Brief introduction of 1228779-96-1

As the paragraph descriping shows that 1228779-96-1 is playing an increasingly important role.

1228779-96-1, 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Into a 40-mL round-bottom flask, was placed 4-(4- ((4?-chloro-5 ,5-dimethyl-3 ,4,5,6-tetrahydro- [1,1 ?-biphenylj -2-yl)methyl)piperazin- 1 -yl) -2-(3 – methoxy-3 ,4-dthydro-2H-pyrrolo [3?,2?:5,6 jpyrido [2,3-bj [1 ,4joxazepin- 1 (7H)-yl)benzoic acid (50 mg, 0.08 mmol, 1 equiv), DCM (3 mL), 3-nitro-4-[[(oxan-4-yl)methyljaminojbenzene-1- sulfonamide (25.2 mg, 0.08 mmol, 1.00 equiv), EDCI (30.6 mg, 0.16 mmol, 2 equiv), DMAP (39.0 mg, 0.32 mmol, 4 equiv). The resulting solution was stirred for overnight at 25 degrees C. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column with dichloromethane/methanol(10:1). The crude product was purified by Flash-PrepHPLC with the following conditions (IntelFlash-1): Column, C18 reversed phase column; mobile phase, Water (1OMMOL/L NH4HCO3+0.05%NH3.H20) and CH3CN (20.0% CH3CN up to 90.0% in 30 mm); Detector, UV 220 nm. This resulted in 32 mg (40.0%) of 4-(4-((4?-chloro- 5 ,5-dimethyl-3 ,4,5,6-tetrahydro- [1,1 ?-biphenylj -2-yl)methyl)piperazin- 1 -yl) -2-(3 -methoxy-3 ,4- dthydro-2H-pyrrolo [3?,2?:5,6 jpyrido [2,3-bj [1 ,4 joxazepin- 1 (7H)-yl)-N-((3-nitro-4-(((tetrahydro- 2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide as a yellow solid. LC-MS: (ES, m/z):M+1=953, R,T= 3.44 mm. ?H NMR (300 MHz, DMSO-d6 ppm) 11.00 (ds, 1H), 8.56 (s, 2H), 7.47-7.44 (m, 2H), 7.36-7.33 (m, 2H), 7.08-7.04 (m, 3H), 6.78-6..65 (m, 2H), 6.57-6.54 (m, 1H),6.43 (s, 1H), 6.04 (s, 1H), 4.05-3.15 (m, 20H), 3.13 (s, 1H), 2.70-2.35 (m, 4H), 2.03 (s, 3H),1.92-1.90 (m, 1H), 1.89-1.87 (m, 2H), 1.7 1-1.67 (m, 2H), 1.53-1.45 (m, 3H), 0.97 (s, 6H)., 1228779-96-1

As the paragraph descriping shows that 1228779-96-1 is playing an increasingly important role.

Reference£º
Patent; NEWAVE PHARMACEUTICAL INC.; CHEN, Yi; LOU, Yan; (108 pag.)WO2019/40550; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics