With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.388109-26-0,Ethyl 3-oxotetrahydro-2H-pyran-4-carboxylate,as a common compound, the synthetic route is as follows.
388109-26-0, To the intermediate 4 (500 mg, 1.87 mmol) in EtOH (50 mL), ethyl 3-oxotetrahydro-2H- pyran-4-carboxylate (0.55 mL, 3.74 mmol, 2 eq.) and AcOH (1.07 mL, 18.69 mmol, 10 eq.) were added. The reaction mixture was stirred at reflux for 2 hours then cooled to room temperature and evaporated under reduce pressure. The residue was triturated in DIPE. Theprecipitate was filtered to give intermediate 44 (675 mg, 100 % pure, 96 % yield).LCMS (M + 1) = 375.1H NMR (400 MHz, DMSO-d6) oe ppm 1.31 – 1.47 (m, 11 H) 1.56 (br. s., 2 H) 1.70 (d,J5.06 Hz, 1 H) 2.32 (d, J12.98 Hz, 1 H) 2.44 – 2.48 (m, 2 H) 2.70 – 2.88 (m, 1 H) 3.81 -3.96 (m, 3 H) 4.51 (s, 2 H) 5.32 (br. s., 1 H) 5.77 (s, 1 H) 12.08 (br. s., 1 H).
The synthetic route of 388109-26-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; JANSSEN SCIENCES IRELAND UC; TAHRI, Abdellah; VENDEVILLE, Sandrine, Marie, Helene; JONCKERS, Tim, Hugo, Maria; RABOISSON, Pierre, Jean-Marie, Bernard; DEMIN, Samuel, Dominique; HU, Lili; (68 pag.)WO2016/91791; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics