With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61363-56-2,2H-Pyran-3,5(4H,6H)-dione,as a common compound, the synthetic route is as follows.
Compound II (22.80 g, 0.2 mol, 1.0 e.q.) was dissolved in EtOH (300 mL) and p-toluenesulfonylhydrazide (37.25 g, 0.2 mol, 1.0 e.q.) was added.Heat to 60 C, stir the reaction for 2 h, remove the solvent under reduced pressure, add pyridine (23.73 g, 0.3 mol, 1.5 e.q.), 300 mL DCM,Subsequently, 60 mL of a DCM solution of NBS (53.39 g, 0.3 mol, 1.5 e.q.) was added dropwise, and the reaction was stirred at 20-30 C until the starting material disappeared.Add 10% hydrochloric acid to adjust the pH to 2-3, separate the liquid, dry the organic phase, and purify by concentrated sand column chromatography.The compound III-1 was obtained as a yellow oil, 26.06 g, yield 73.6%.
The synthetic route of 61363-56-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Nanjing Yaoshi Technology Co., Ltd.; Nanjing Furunkaide Bio-pharmaceutical Co., Ltd.; Li Jilong; Fei Qinlong; Li Hui; (13 pag.)CN108558806; (2018); A;,
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