61363-56-2, 2H-Pyran-3,5(4H,6H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,61363-56-2
2H-Pyran-3, 5(41-1, 6H)-dione (1.36 g, 11.6 mmol) was dissolved in EtOH (50 mL) and cone, sulfuric acid (1.5 mL) added. The reaction was stirred at ambient temperature overnight. The reaction was concentrated to remove the EtOH and basified (pH ~8) with saturated aqueous NaHCOs solution. (4065) The resulting brown solution was extracted with EtOAc (3 x 50 mL). The combined organic extracts were dried over Na2S04 and concentrated in vacuo. The resulting crude oil was purified by column chromatography eluting with a 0-100% gradient of EtOAc in isohexane. Product-containing fractions were combined and concentrated to afford the title compound (331 mg, 20 % Yield). dH (300 MHz, Chloroform-cf) 5.46 (s, 1H), 4.25 (s, 2H), 4.08 (d, J = 0.8 Hz, 2H), 3.99 (q, J = 7.0 Hz, 2H), 1.39 (t, J = 7.0 Hz, 3H).
The synthetic route of 61363-56-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; UCB BIOPHARMA SRL; CHOVATIA, Prafulkumar Tulshibhai; CONNELLY, Rickki Lee; FRANKLIN, Richard Jeremy; HASLETT, Gregory William; HENRY, Alistair James; MADDEN, James; NEUSS, Judi Charlotte; NORMAN, Timothy John; PHILPS, Oliver; PITT, William Ross; RAMPALAKOS, Konstantinos; SELBY, Matthew Duncan; SELVARATNAM, Suganthan; TRANI, Giancarlo; ZHU, Zhaoning; (768 pag.)WO2019/243550; (2019); A1;,
Tetrahydropyran – Wikipedia
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