185815-59-2, 4-Isobutyldihydro-2H-pyran-2,6(3H)-dione is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 2: Preparation of (3R)-5-methyl-3 -(2-oxo-2 (F(I RVl -phenylethyll amino lethvD hexanoic acid compound (24); [0076] A three-necked flask equipped with an addition funnel, thermometer pocket , drying tube and mechanical stirrer, was charged with ethyl acetate (100 ml), (R)-(+)- phenylethylamine (26.69 g, 0.0.22mole) and 4-dimethylaminopyridine (2.69 g, 0.15. mole). The mixture was cooled to a temperature of -50 to -60 C, followed by addition of a solution of 3-isobutyl glutaric anhydride (25 g, 0.147 mole) in ethyl acetate (50 ml), over a period of 25-30 minutes, and stirring for additional 1.5-2 hours, at a temperature of -50 to -60C. The mixture was then extracted with 5-4 percent aqueous solution of NaOH (500 ml), and the aqueous phase was separated. The pH of the aqueous phase was adjusted to 2-2.5 by adding a solution hydrochloric acid (1-12N). The aqueous phase was further extracted with ethyl acetate (1 x 150 ml and 1 x 100 ml), followed by drying the combined ethyl acetates extracts over anhydrous sodium sulfate, and stripping off the solvent to obtain a residue. The residue was crystallized from ethyl acetate and toluene mixture to get 35.43 g (82.87 percent yield) of a white solid of (3R)-5-methyl-3-(2-oxo-2-{[(lR)-l-phenylethyl]amino}ethyl) hexanoic acid with an optical purity of 99.4 percent, as measured by chiral HPLC., 185815-59-2
185815-59-2 4-Isobutyldihydro-2H-pyran-2,6(3H)-dione 11480690, aTetrahydropyrans compound, is more and more widely used in various.
Reference£º
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2007/35789; (2007); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics