With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.951127-25-6,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.
A solution of 11 (2.5 g, 7.64 mmol) was added to 40 mL of toluene and morpholine (1.30 g, 15.30 mmol) was added. The reaction was heated to reflux and the water was separated with a water separator for 6 hours. The reaction solution was allowed to cool to room temperature and the solid was collected by filtration and washed with toluene to give 1 J (2.1 g, yield 70%) as a white solid.
951127-25-6 tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate 44193925, aTetrahydropyrans compound, is more and more widely used in various.
Reference£º
Patent; SICHUAN HAISCO PHARMACEUTICAL CO., LTD; ZHANG, CHEN; FAN, JIANG; LI, CAI-HU; WEI, YONG-GANG; (99 pag.)TW2017/8222; (2017); A;,
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