With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127956-11-0,Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate,as a common compound, the synthetic route is as follows.
The pyranone-2-carboxylic acid methyl ester was first poured into the autoclave and the temperature was lowered to -78C.The temperature was added with hydrogen fluoride and sulfur tetrafluoride, the molar ratio of beta-keto acid ester and SF4 and HF was 1:3:18, and the temperature was raised to 100C. The reaction was carried out for 24 hours to obtain the intermediate 1,1-difluoro-2-pyrancarboxylic acid. Methyl esters.The reaction solution was diluted with water and then extracted with ethyl acetate.The aqueous phase was washed twice with saturated sodium bicarbonate solution and the organic phase was dried and spin-dried to give the intermediate 1,1-difluoro-2-pyrancarboxylic acid methyl ester., 127956-11-0
127956-11-0 Methyl 4-oxotetrahydro-2H-pyran-3-carboxylate 14666555, aTetrahydropyrans compound, is more and more widely used in various.
Reference£º
Patent; Wuhan Yao Ming Kant, Immanuel New Drug Development Co., Ltd.; He Xin; Wu Rongfu; Liu Zhouya; Ma Jianyi; Zhang Zhiliu; Jiang Luyong; Ma Rujian; (6 pag.)CN107903205; (2018); A;,
Tetrahydropyran – Wikipedia
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