With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1228779-96-1,3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide,as a common compound, the synthetic route is as follows.
A mixture of 2- ((1H-pyrrolo [2, 3-b] pyridin-5-yl) oxy)-4-(4-oxocyclohexyl) benzoic acid (2.0g, 5.71mmol), 3-nitro-4- (((tetrahydro-2H-pyran-4-yl) methyl) amino) benzene sulfonamide (1.8 g, 5.71 mmol), EDCI (1.64 g, 8.57 mmol), DMAP (1.05 g, 8.57 mmol) and TEA (1.15 g, 16.42 mmol) in DCM (20 mL) was stirred at ambient temperature for 20 hours. The reaction mixture was concentrated in vacuum, then purified by chromatography column on silica (eluent: DCM/MeOH = 100/1 to 50/1) to afford 2- ((1H-pyrrolo [2, 3-b] pyridin-5-yl) oxy) -N- ((3- nitro-4- (((tetrahydro-2H-pyran-4-yl) methyl) amino) phenyl) sulfonyl)-4-(4-oxocyclohexyl) benzamide (1.5 g). MS (ESI) m/e [M+1] + 648.1.
1228779-96-1, The synthetic route of 1228779-96-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BEIGENE, LTD.; GUO, Yunhang; XUE, Hai; WANG, Zhiwei; SUN, Hanzi; (493 pag.)WO2019/210828; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics