Application of 951127-25-6, Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.951127-25-6, Name is tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pyran-3-yl)carbamate, molecular formula is C16H19F2NO4. In a patent, introducing its new discovery.
The invention discloses a method for preparing compound, including the compound 3 5 – amino – 6 – (2, 5 – difluorophenyl) – tetrahydro – 2H – pyran – 3 – ol chemical splitting, and obtain the compound 3 with the resolving agent to form a salt; the compound 3 with the resolving agent in the alkali salt in the form of di-T-butyl ester with the chemical combination to obtain compound 4; the compound 4 is oxidized formula 1 compounds of formula N – [(2R, 3S) – 2 – (2, 5 – difluorophenyl) tetrahydro – 5 – oxo – 2H – pyran – 3 – yl] – carbamic acid 1, 1 – dimethyl ethyl ester. Preparation method of this invention, by selecting the low price of the raw material, shorter synthetic routes, omit the asymmetric hydrogenation reaction steps, so as to greatly reduce the production cost, but also significantly improves the yield. (by machine translation)
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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics