Final Thoughts on Chemistry for (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal

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Synthetic Route of 499-40-1. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 499-40-1, Name is (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal. In a document type is Article, introducing its new discovery.

The nickel(ii) complexes with the non-steroidal anti-inflammatory drug naproxen (Hnap) were prepared in the absence or presence of the nitrogen-donor heterocyclic ligands 2,2?-bipyridine (bipy), 1,10-phenanthroline (phen), 2,2?-bipyridylamine (bipyam), 2,2?-dipyridylketone oxime (Hpko) or pyridine (py) and were characterized by diverse techniques. The crystal structures of complexes [Ni(nap-O)(nap-O,O?)(bipy)(MeOH)], 2 and [Ni(nap-O)(nap-O,O?)(phen)(H2O)] 3 were determined by X-ray crystallography. The antioxidant activity of the complexes was evaluated in vitro by examining their ability to scavenge 1,1-diphenyl-picrylhydrazyl, 2,2?-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) and hydroxyl radicals and to inhibit soybean lipoxygenase. The ability of the complexes to intercalate to calf-thymus DNA was monitored by diverse techniques (UV-vis spectroscopy, cyclic voltammetry, viscosity measurements) and competitive studies with ethidium bromide. The interaction of the complexes with serum albumins was studied by fluorescence emission spectroscopy and the corresponding binding constants were calculated. The bio-activity of the complexes was compared to previously reported metal-naproxen complexes and the structural factors responsible for enhanced activity are discussed.

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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics