Analyzing the synthesis route of 101691-94-5

101691-94-5, As the paragraph descriping shows that 101691-94-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101691-94-5,4-(Iodomethyl)tetrahydro-2H-pyran,as a common compound, the synthetic route is as follows.

A mixture of tert-butyl 5- (6-cyclopropyl-2-oxo- 1 ,2-dthydropyridine-4-carbonyl)-3 ,4,5 ,6-tetrahydropyrrolo [3 ,4-c]pyrrole-2( 1 H)-carboxylate (385 mg, 985 j.imol), potassium carbonate(272 mg, 1.97 mmol) and 4-(iodomethyl)tetrahydro-2H-pyran (459 mg, 1.97 mmol) inacetonitrile (8 mL) was heated at 90C for 48 h, then partitioned between sat. aq. ammoniumchloride solution and ethyl acetate. The organic layer was washed with brine, dried overmagnesium sulfate, filtered and evaporated. The residue was chromatographed (silica gel; gradient dichloromethane to dichloromethane/methanol/25 % aq. ammonia solution 95:5:0.25) to produce the title compound (390 mg, 84%). White foam, MS: 470.3 (M+H).

101691-94-5, As the paragraph descriping shows that 101691-94-5 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DI GIORGIO, Patrick; HERT, Jerome; HUNZIKER, Daniel; MATTEI, Patrizio; RUDOLPH, Markus; SCHMITZ, Petra; ULLMER, Christoph; (88 pag.)WO2017/50791; (2017); A1;,
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