220641-87-2, N-Methyltetrahydro-2H-pyran-4-amine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of N-methyltetrahydro-2H-pyran-4-ammonium chloride (37 mg) in dichloromethane (2 mL) was added DIPEA (43 mul), compound 48-2 (29 mg) and molecular sieves (200 mg). The reaction mixture was stirred at room temperature for 10 minutes, followed by the addition of sodium triacetoxyborohydride (52 mg). After stirring 18 hours, the reaction mixture was diluted with CH2Cl2, washed with saturated NaHCO3 and brine, dried over anhydrous sodium sulfate, filtered and concentrated to give a residue. The residue was purified by prep TLC on silica gel (dichloromethane/methanol / 15N NH40H aqueous solution = 90 : 9 : 1 ) to give compound 48-3. ESI-MS calc.for C37H46ClF2N5O3: 681; Found: 682 (M+H).
220641-87-2, As the paragraph descriping shows that 220641-87-2 is playing an increasingly important role.
Reference£º
Patent; MERCK & CO., INC.; WO2007/47496; (2007); A2;,
Tetrahydropyran – Wikipedia
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