389621-77-6, 2-(Tetrahydro-2H-pyran-4-yl)ethanamine hydrochloride is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
DIPEA (7.99 mL, 45.8 mmol) was added to a suspension of 2-(tetrahydro-2H-pyran-4- [ 5 yl)ethanamine hydrochloride (3.63 g, 21.89 mmol) in THF (30 mL, 366 mmol) and stirred for 15 min. A solution of 4-(4-fluoro-3-nitrophenyl)-3,5-dimethylisoxazole (4.7 g, 19.90 mmol) in THF (40 mL, 488 mmol) was added to the suspension and stirred at RT for a further 2h. DMF (10 mL, 129 mmol) was added and the reaction stirred at RT for a further 2h. The reaction was heated at 50C for 20h and then at 70C for a further 10 20h. The solvent volume was reduced by evaporation in vacuo and the residue diluted with EtOAc (200 mL). The solution was washed with water (3 x 50mL) and brine (30 mL), dried (MgS04), filtered and evaporated in vacuo. The residual solid was purified by chromatography on the Companion (220 g column, 0-30% EtOAc in (2: 1 DCM/isohexane), loaded in DCM) to give 4-(3,5-dimethylisoxazol-4-yl)-2-nitro-N-(2- 15 (tetrahydro-2H-pyran-4-yl)ethyl)aniline (5.6 g, 80%) as a orange solid; m/z 346 (M+H)+ (ES+).
389621-77-6, As the paragraph descriping shows that 389621-77-6 is playing an increasingly important role.
Reference£º
Patent; CELLCENTRIC LTD; PEGG, Neil Anthony; TADDEI, David Michel Adrien; ONIONS, Stuart Thomas; TSE, Eric Sing Yuen; BROWN, Richard James; MYCOCK, David Kenneth; COUSIN, David; PATEL, Anil; (135 pag.)WO2016/170324; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics