33024-60-1, Tetrahydro-2H-pyran-4-amine hydrochloride is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 1 (2. [5G)] was dissolved in acetonitrile [(15ML).] 4-Aminotetrahydropyran hydrochloride [(1.] [LG)] and N, N-diisopropylethylamine (9. [4ML)] were added and the mixture stirred under nitrogen at [85¡ãC] for 16h. A trace of starting material remained, so an additional portion of 4-aminotetrahydropyran hydrochloride [(O.] [L] lg) was added and stirring continued at [85¡ãC] for a further [16H.] The mixture was then concentrated in vacuo. The residue was partitioned between DCM and water. The layers were separated and the organic layer was washed with further water [(2X20ML)] then dried [(NA2S04)] and concentrated in vacuo. The residue was further purified by chromatography using Biotage (silica, 90g), eluting with cyclohexane: ethyl acetate to afford Example 3 (2.45g). LCMS showed MH+ [= 319] ; TRET = 2. [90MIN.]
33024-60-1, The synthetic route of 33024-60-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/24728; (2004); A2;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics